School of Medical Sciences, Orebro University, Orebro, Sweden.
Department of Biomedicine, University of Bergen, Bergen, Norway.
PLoS One. 2020 Jun 18;15(6):e0234561. doi: 10.1371/journal.pone.0234561. eCollection 2020.
Attention-deficit/hyperactivity disorder (ADHD) has been associated with an increased risk of tobacco smoking, and more difficulties with smoking cessation compared to non-ADHD individuals. Women with ADHD may therefore show elevated rates of smoking during pregnancy.
To examine the association between ADHD and smoking habits among pregnant women in Sweden and Norway.
Women pregnant for the first time were identified in Sweden (n = 622,037), and Norway (n = 293,383), of which 1.2% (n = 7,444), and 1.7% (n = 4,951) were defined as having ADHD, respectively. Data on smoking habits were collected early and late in pregnancy.
In Sweden, ADHD was associated with an increased risk of smoking early in pregnancy, adjusted risk ratio (adjRR) 2.69 (95% confidence interval, 2.58-2.81), and late in pregnancy, adjRR 2.95 (2.80-3.10). Similar findings were observed in the Norwegian data, early in pregnancy, adjRR 2.31 (2.21-2.40), and late in pregnancy, adjRR 2.56 (2.42-2.70). Women with ADHD were more likely to continue smoking during pregnancy, compared to women without ADHD, both in Sweden adjRR 1.13 (1.10-1.17), and in Norway, adjRR 1.16 (1.12-1.20). Having a sibling diagnosed with ADHD was associated with an increased risk of smoking early and late in pregnancy, in both Sweden and Norway.
Women with ADHD are considerably more likely to smoke early and late in (their first) pregnancy and are less likely to stop smoking between the two time points. Smoking, early and late in pregnancy, co-aggregates in families with ADHD. Smoking prevention and intervention programs should be targeted towards women with ADHD, specifically during their childbearing years, to ensure better mother and child outcomes.
注意力缺陷多动障碍(ADHD)与吸烟风险增加有关,与非 ADHD 个体相比,ADHD 患者在戒烟方面也面临更多困难。因此,女性 ADHD 患者在怀孕期间可能会有更高的吸烟率。
在瑞典和挪威,检查 ADHD 与孕妇吸烟习惯之间的关联。
在瑞典(n=622037)和挪威(n=293383)首次怀孕的女性中确定患有 ADHD 的患者,分别有 1.2%(n=7444)和 1.7%(n=4951)被诊断为患有 ADHD。在妊娠早期和晚期收集吸烟习惯数据。
在瑞典,ADHD 与妊娠早期吸烟风险增加相关,调整后的风险比(adjRR)为 2.69(95%置信区间,2.58-2.81),妊娠晚期为 2.95(2.80-3.10)。在挪威的数据中也观察到类似的发现,妊娠早期的 adjRR 为 2.31(2.21-2.40),妊娠晚期为 2.56(2.42-2.70)。与没有 ADHD 的女性相比,患有 ADHD 的女性在怀孕期间更有可能继续吸烟,在瑞典 adjRR 为 1.13(1.10-1.17),在挪威,adjRR 为 1.16(1.12-1.20)。在瑞典和挪威,患有 ADHD 的兄弟姐妹与妊娠早期和晚期吸烟风险增加有关。
患有 ADHD 的女性在妊娠早期和晚期吸烟的可能性明显更高,并且在两个时间点之间停止吸烟的可能性也较低。妊娠早期和晚期的吸烟行为在 ADHD 家庭中共同聚集。应该针对 ADHD 女性,特别是在生育年龄期间,开展吸烟预防和干预计划,以确保母婴的更好结局。