产前烟草暴露与6岁和8岁时注意缺陷多动障碍相关特征之间的关联：日本的一项出生队列研究

Association between prenatal tobacco exposure and attention-deficit/hyperactivity disorder related characteristics at 6 and 8 years: a birth cohort in Japan.

作者信息

Itoh Mariko, Kobayashi Sumitaka, Nishihara Shinkichi, Miyashita Chihiro, Yamazaki Keiko, Tamura Naomi, Suyama Satoshi, Ikeda Atsuko, Itoh Sachiko, Ait Bamai Yu, Yamaguchi Takeshi, Masuda Hideyuki, Hanley Sharon, Kishi Reiko

机构信息

Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.

Division of Epidemiological Research for Chemical Disorders, Research Center for Chemical Information and Management, National Institute of Occupational Safety and Health Japan, Kawasaki, Kanagawa, Japan.

出版信息

BMJ Open. 2024 Dec 26;14(12):e087406. doi: 10.1136/bmjopen-2024-087406.

DOI:10.1136/bmjopen-2024-087406

PMID:39725438

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11683938/

Abstract

OBJECTIVES

To examine the association between maternal plasma cotinine concentrations during pregnancy and attention-deficit/hyperactivity disorder (ADHD) related characteristics in children.

DESIGN

Prospective birth cohort study from the Hokkaido Study on Environment and Children's Health.

SETTING

Hokkaido, Japan.

PARTICIPANTS

A total of 7217 children were included in the analysis. Their mothers were recruited to this study between 2003 and 2012 during early pregnancy. Blood samples of mothers in their third trimester of pregnancy were obtained.

MAIN OUTCOME MEASURES

ADHD-related characteristics screened by the ADHD-Rating Scale (ADHD-RS) in children at 6 and 8 years of age.

RESULTS

The mothers were classified into three groups according to plasma cotinine levels (median=0.22 ng/mL)-non-smokers (≤0.21 ng/mL), passive smokers (0.22-11.48 ng/mL) and active smokers (≥11.49 ng/mL). ADHD was suspected in 302 (8.6%), 334 (10.9%) and 90 (14.5%) children in the non-smoker, passive smoker and active smoker groups, respectively. Children born to mothers in the smoking group had a statistically significant increased risk of ADHD-related characteristics (adjusted RR=1.49, 95% CI=1.19-1.86 and adjusted RR=1.20, 95% CI=1.03-1.40 for the active and passive smoking groups, respectively).

CONCLUSION

This large Japanese cohort study suggests an association between smoking during pregnancy and the risk of ADHD in children 6 and 8 years of age.

摘要

目的

研究孕期母亲血浆可替宁浓度与儿童注意力缺陷多动障碍（ADHD）相关特征之间的关联。

设计

来自北海道环境与儿童健康研究的前瞻性出生队列研究。

地点

日本北海道。

参与者

共有7217名儿童纳入分析。他们的母亲于2003年至2012年孕早期被招募入本研究。采集了母亲孕晚期的血样。

主要观察指标

采用ADHD评定量表（ADHD-RS）对6岁和8岁儿童的ADHD相关特征进行筛查。

结果

根据血浆可替宁水平（中位数 = 0.22 ng/mL），母亲被分为三组——非吸烟者（≤0.21 ng/mL）、被动吸烟者（0.22 - 11.48 ng/mL）和主动吸烟者（≥11.49 ng/mL）。非吸烟者、被动吸烟者和主动吸烟者组中分别有302名（8.6%）、334名（10.9%）和90名（14.5%）儿童被怀疑患有ADHD。吸烟组母亲所生儿童出现ADHD相关特征的风险在统计学上显著增加（主动吸烟组和被动吸烟组的调整风险比分别为1.49，95%可信区间 = 1.19 - 1.86；1.20，95%可信区间 = 1.03 - 1.40）。