肠道病毒71型（EV71）3C蛋白酶的功能与机制
The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease.
作者信息
Wen Weihui, Qi Zixuan, Wang Jing
机构信息
Department of Microbiology, School of Medicine, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
School of Medicine, Forth Clinical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
出版信息
Curr Microbiol. 2020 Sep;77(9):1968-1975. doi: 10.1007/s00284-020-02082-4. Epub 2020 Jun 15.
Enterovirus 71 (EV71) is the main pathogen of the hand, foot, and mouth disease. It was firstly isolated from sputum specimens of infants with central nervous system diseases in California in 1969, and has been repeatedly reported in various parts of the world, especially in the Asia-Pacific region. EV71 3C protein is a 183 amino acid cysteine protease that can cleave most structural and non-structural proteins of EV71. Based on the analysis and understanding of EV71 3C protease, it is helpful to study and treat diseases caused by EV71 virus infection. The EV71 3C protease promotes virus replication by cleaving EV71 synthesis or host proteins. Moreover, EV71 3C protease inhibits the innate immune system and causes apoptosis. At present, in order to deal with the damage caused by the EV71, it is urgent to develop antiviral drugs targeting 3C protease. This review will focus on the structure, function, and mechanism of EV71 3C protease.
肠道病毒71型（EV71）是手足口病的主要病原体。它于1969年首次从加利福尼亚州患有中枢神经系统疾病的婴儿痰液标本中分离出来，并且在世界各地区都有反复报道，尤其是在亚太地区。EV71 3C蛋白是一种由183个氨基酸组成的半胱氨酸蛋白酶，它可以切割EV71的大多数结构蛋白和非结构蛋白。基于对EV71 3C蛋白酶的分析和理解，有助于研究和治疗由EV71病毒感染引起的疾病。EV71 3C蛋白酶通过切割EV71合成蛋白或宿主蛋白来促进病毒复制。此外，EV71 3C蛋白酶会抑制先天性免疫系统并导致细胞凋亡。目前，为了应对EV71造成的损害，迫切需要开发针对3C蛋白酶的抗病毒药物。本综述将聚焦于EV71 3C蛋白酶的结构、功能和作用机制。
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