Department of Neurosurgery, Great Ormond Street Hospital, London, UK.
UCL Cancer Institute, University College London, London, UK.
Childs Nerv Syst. 2020 Sep;36(9):1869-1886. doi: 10.1007/s00381-020-04724-1. Epub 2020 Jun 18.
Optic pathway gliomas (OPGs), also known as Visual Pathway Gliomas, are insidious, debilitating tumours. They are most commonly WHO grade 1 pilocytic astrocytomas and frequently occur in patients with neurofibromatosis type 1. The location of OPGs within the optic pathway typically precludes complete resection or optimal radiation dosing, hence outcomes remain poor compared to many other low-grade gliomas. The aim of this systematic review was to formulate a comprehensive list of all current ongoing clinical trials that are specifically looking at clinical care of OPGs in order to identify trends in current research and provide an overview to guide future research efforts.
This systematic review was conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The Cochrane Controlled Register of Trials (CENTRAL) and ClinicalTrials.gov were searched. Inclusion and exclusion criteria were applied and final results were reviewed.
501 clinical trials were identified with the search strategy. All were screened and eligible studies extracted and reviewed. This yielded 36 ongoing clinical trials, 27 of which were pharmacological agents in phase I-III. The remaining trials were a mixture of biological agents, radiation optimisation, diagnostic imaging, surgical intervention, and a social function analysis.
OPG is a complex multifaceted disease, and advances in care require ongoing research efforts across a spectrum of different research fields. This review provides an update on the current state of research in OPG and summarises ongoing trials.
视神经胶质瘤（OPGs），也称为视觉通路胶质瘤，是一种隐匿性、使人虚弱的肿瘤。它们通常为 WHO 分级 1 级毛细胞型星形细胞瘤，常发生于神经纤维瘤病 1 型患者中。OPGs 在视神经通路中的位置通常排除了完全切除或最佳放疗剂量，因此与许多其他低级别胶质瘤相比，其结果仍然较差。本系统评价的目的是制定一份全面的当前正在进行的临床试验清单，专门研究 OPG 的临床护理，以确定当前研究趋势，并提供概述以指导未来的研究工作。
本系统评价按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行。检索了 Cochrane 对照试验注册库（CENTRAL）和 ClinicalTrials.gov。应用纳入和排除标准，并对最终结果进行了审查。
通过搜索策略确定了 501 项临床试验。所有试验均进行了筛选，提取并审查了合格的研究。这产生了 36 项正在进行的临床试验，其中 27 项处于 I-III 期的药理制剂。其余试验为生物制剂、放疗优化、诊断成像、手术干预和社会功能分析的混合。
OPG 是一种复杂的多方面疾病，需要在不同研究领域进行持续的研究工作来推动治疗进展。本综述提供了 OPG 研究现状的最新信息，并总结了正在进行的试验。
