视路胶质瘤的神经免疫调节及潜在治疗策略
The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma.
作者信息
Irshad Khushboo, Huang Yu-Kai, Rodriguez Paul, Lo Jung, Aghoghovwia Benjamin E, Pan Yuan, Chang Kun-Che
机构信息
Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
出版信息
Brain Sci. 2023 Oct 7;13(10):1424. doi: 10.3390/brainsci13101424.
Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.
视路胶质瘤（OPG）是儿童视力损害的病因之一。不幸的是，目前尚无治愈这种疾病的方法。了解其潜在机制和潜在治疗策略可能有助于延缓OPG的进展并挽救视力损害。在此，我们概述了临床前OPG研究以及控制OPG病理生理学的调控途径。接下来，我们讨论微环境细胞（神经元、T细胞以及肿瘤相关小胶质细胞和巨噬细胞）在OPG发展中的作用。最后，我们深入探讨治疗OPG和促进轴突再生的潜在治疗策略。
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