Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, Australia.
Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC 3002, Australia.
Int J Mol Sci. 2020 Jun 16;21(12):4273. doi: 10.3390/ijms21124273.
Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural reprogramming methods have been established, using pluripotent stem cells (PSCs) or direct reprogramming, to efficiently derive specific neuronal cell types for therapeutic applications. Both in vitro and in vivo cellular reprogramming provide diverse therapeutic pathways for modeling neurological diseases and injury repair. In particular, the retina has emerged as a promising target for clinical application of regenerative medicine. Herein, we review the potential of neuronal reprogramming to develop regenerative strategy, with a particular focus on treating retinal degenerative diseases and discuss future directions and challenges in the field.
干细胞和细胞重编程技术代表了再生医学中一个快速发展的领域。已经建立了许多新的神经重编程方法，使用多能干细胞（PSCs）或直接重编程，以有效地衍生出特定的神经元细胞类型用于治疗应用。体外和体内细胞重编程为神经疾病和损伤修复的模型提供了多种治疗途径。特别是，视网膜已成为再生医学临床应用的一个很有前途的靶点。在此，我们综述了神经元重编程在开发再生策略方面的潜力，特别是在治疗视网膜退行性疾病方面，并讨论了该领域的未来方向和挑战。
