National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell Res. 2014 Feb;24(2):141-2. doi: 10.1038/cr.2013.165. Epub 2013 Dec 17.
A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative medicine and may also minimize the concerns associated with in vitro culture and cell transplantation.
在再生医学中，一个主要的挑战是生成具有功能有效性的靶细胞，以替代或修复受损组织。体内转分化是一种在天然生理龛内实现细胞命运转换的新策略；该技术可能为再生医学中的应用提供一种更具时间和成本效益的替代方案，并且还可能最小化与体外培养和细胞移植相关的问题。
