来自[具体物种]的二萜类化合物作为通过凋亡发挥作用的潜在化疗药物。 （你提供的原文中“spp.”处信息不完整，这里只能按格式大致翻译，完整准确翻译需补充完整“spp.”指代的内容）
Diterpenoids from spp. as Potential Chemotherapeutic Agents via Apoptosis.
作者信息
Śliwiński Tomasz, Sitarek Przemysław, Skała Ewa, Isca Vera M S, Synowiec Ewelina, Kowalczyk Tomasz, Bijak Michał, Rijo Patrícia
机构信息
Laboratory of Medical Genetics, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
出版信息
Pharmaceuticals (Basel). 2020 Jun 16;13(6):123. doi: 10.3390/ph13060123.
spp. is widely known for its medicinal properties and bioactive metabolites.The cytotoxic and genotoxic properties of the four known abietane diterpenoids: 7α-Acetoxy-6β-hydroxyroyleanone (Roy), 6,7-dehydroroyleanone (Deroy), 7β,6β-dihydroxyroyleanone6 (Diroy),and Parvifloron D (Parv), isolated from (Roy, DeRoy, and Diroy) and (Parv) were evaluated. The tested compounds showed cytotoxic effects against the human leukemiacell line CCRF-CEM and the lung adenocarcinoma cell line A549. All tested compounds inducedapoptosis by altering the level of pro- and anti-apoptotic genes. The results show that from the testedditerpenoids, Roy and Parv demonstrated the strongest activity in both human cancer cell lines,changing the permeability mitochondrial membrane potential and reactive oxygen species (ROS)levels, and possibly inducing mtDNA or nDNA damage. In conclusion, the abietane diterpenoidstested may be used in the future as potential natural chemotherapeutic agents.
该物种因其药用特性和生物活性代谢产物而广为人知。对从[具体来源未给出]分离出的四种已知松香烷二萜类化合物：7α-乙酰氧基-6β-羟基罗叶酮（Roy）、6,7-脱氢罗叶酮（Deroy）、7β,6β-二羟基罗叶酮6（Diroy）和小花木兰素D（Parv）的细胞毒性和基因毒性特性进行了评估。测试的化合物对人白血病细胞系CCRF-CEM和肺腺癌细胞系A549显示出细胞毒性作用。所有测试化合物通过改变促凋亡和抗凋亡基因的水平诱导细胞凋亡。结果表明，在所测试的二萜类化合物中，Roy和Parv在两种人类癌细胞系中均表现出最强的活性，改变线粒体膜电位和活性氧（ROS）水平，并可能诱导线粒体DNA或核DNA损伤。总之，所测试的松香烷二萜类化合物未来可能用作潜在的天然化疗药物。
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