• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

来自[具体物种]的二萜类化合物作为通过凋亡发挥作用的潜在化疗药物。 （你提供的原文中“spp.”处信息不完整，这里只能按格式大致翻译，完整准确翻译需补充完整“spp.”指代的内容）

Diterpenoids from spp. as Potential Chemotherapeutic Agents via Apoptosis.

作者信息

Śliwiński Tomasz, Sitarek Przemysław, Skała Ewa, Isca Vera M S, Synowiec Ewelina, Kowalczyk Tomasz, Bijak Michał, Rijo Patrícia

机构信息

Laboratory of Medical Genetics, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.

Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.

出版信息

Pharmaceuticals (Basel). 2020 Jun 16;13(6):123. doi: 10.3390/ph13060123.

DOI:10.3390/ph13060123
PMID:32560101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7344685/
Abstract

spp. is widely known for its medicinal properties and bioactive metabolites.The cytotoxic and genotoxic properties of the four known abietane diterpenoids: 7α-Acetoxy-6β-hydroxyroyleanone (Roy), 6,7-dehydroroyleanone (Deroy), 7β,6β-dihydroxyroyleanone6 (Diroy),and Parvifloron D (Parv), isolated from (Roy, DeRoy, and Diroy) and (Parv) were evaluated. The tested compounds showed cytotoxic effects against the human leukemiacell line CCRF-CEM and the lung adenocarcinoma cell line A549. All tested compounds inducedapoptosis by altering the level of pro- and anti-apoptotic genes. The results show that from the testedditerpenoids, Roy and Parv demonstrated the strongest activity in both human cancer cell lines,changing the permeability mitochondrial membrane potential and reactive oxygen species (ROS)levels, and possibly inducing mtDNA or nDNA damage. In conclusion, the abietane diterpenoidstested may be used in the future as potential natural chemotherapeutic agents.

摘要

该物种因其药用特性和生物活性代谢产物而广为人知。对从[具体来源未给出]分离出的四种已知松香烷二萜类化合物：7α-乙酰氧基-6β-羟基罗叶酮（Roy）、6,7-脱氢罗叶酮（Deroy）、7β,6β-二羟基罗叶酮6（Diroy）和小花木兰素D（Parv）的细胞毒性和基因毒性特性进行了评估。测试的化合物对人白血病细胞系CCRF-CEM和肺腺癌细胞系A549显示出细胞毒性作用。所有测试化合物通过改变促凋亡和抗凋亡基因的水平诱导细胞凋亡。结果表明，在所测试的二萜类化合物中，Roy和Parv在两种人类癌细胞系中均表现出最强的活性，改变线粒体膜电位和活性氧（ROS）水平，并可能诱导线粒体DNA或核DNA损伤。总之，所测试的松香烷二萜类化合物未来可能用作潜在的天然化疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/9f7fcb2494b8/pharmaceuticals-13-00123-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/154ffc642bc5/pharmaceuticals-13-00123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/6a3bcd1ebc2b/pharmaceuticals-13-00123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/4c11aa1f6413/pharmaceuticals-13-00123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/d7ae84157238/pharmaceuticals-13-00123-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/95fbc05a7a6e/pharmaceuticals-13-00123-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/91c9adcf71fa/pharmaceuticals-13-00123-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/ba3bfa943c0d/pharmaceuticals-13-00123-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/38a745a74f6f/pharmaceuticals-13-00123-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/e8828b1c70ee/pharmaceuticals-13-00123-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/9e69bd078c77/pharmaceuticals-13-00123-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/9f7fcb2494b8/pharmaceuticals-13-00123-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/154ffc642bc5/pharmaceuticals-13-00123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/6a3bcd1ebc2b/pharmaceuticals-13-00123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/4c11aa1f6413/pharmaceuticals-13-00123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/d7ae84157238/pharmaceuticals-13-00123-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/95fbc05a7a6e/pharmaceuticals-13-00123-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/91c9adcf71fa/pharmaceuticals-13-00123-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/ba3bfa943c0d/pharmaceuticals-13-00123-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/38a745a74f6f/pharmaceuticals-13-00123-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/e8828b1c70ee/pharmaceuticals-13-00123-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/9e69bd078c77/pharmaceuticals-13-00123-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5401/7344685/9f7fcb2494b8/pharmaceuticals-13-00123-g011.jpg

相似文献

1
Diterpenoids from spp. as Potential Chemotherapeutic Agents via Apoptosis.来自[具体物种]的二萜类化合物作为通过凋亡发挥作用的潜在化疗药物。 （你提供的原文中“spp.”处信息不完整，这里只能按格式大致翻译，完整准确翻译需补充完整“spp.”指代的内容）
Pharmaceuticals (Basel). 2020 Jun 16;13(6):123. doi: 10.3390/ph13060123.
2
Insight the Biological Activities of Selected Abietane Diterpenes Isolated from spp.从 spp. 中分离出的几种松香烷二萜的生物活性研究
Biomolecules. 2020 Jan 28;10(2):194. doi: 10.3390/biom10020194.
3
The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells.来自白绒草的枞烷二萜类化合物小花绒草素D是人类白血病细胞中一种有效的凋亡诱导剂。
Phytomedicine. 2015 Oct 15;22(11):1009-16. doi: 10.1016/j.phymed.2015.06.013. Epub 2015 Jul 10.
4
Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma.揭示哈地车前胡素 7α-乙酰氧基-6β-羟基酮在神经胶质瘤中的抗肿瘤机制。
J Ethnopharmacol. 2024 Dec 5;335:118689. doi: 10.1016/j.jep.2024.118689. Epub 2024 Aug 14.
5
Antimycobacterial, Cytotoxic, and Antioxidant Activities of Abietane Diterpenoids Isolated from .从……中分离得到的枞烷二萜类化合物的抗分枝杆菌、细胞毒性和抗氧化活性
Plants (Basel). 2021 Jan 19;10(1):175. doi: 10.3390/plants10010175.
6
Phytochemical Study and Antiglioblastoma Activity Assessment of (Forssk.) Schweinf. ex Sprenger var. hadiensis Stems.（福司氏）沙戟茎的植物化学研究及抗神经胶质瘤活性评估。
Molecules. 2022 Jun 14;27(12):3813. doi: 10.3390/molecules27123813.
7
Self-Assembly Nanoparticles of Natural Bioactive Abietane Diterpenes.天然生物活性枞烷二萜的自组装纳米粒子。
Int J Mol Sci. 2021 Sep 22;22(19):10210. doi: 10.3390/ijms221910210.
8
Anticancer Effects of Abietane Diterpene 7α-Acetoxy-6β-hydroxyroyleanone from and Its Semi-Synthetic Analogs: An In Silico Computational Approach.来自[具体来源未给出]的枞烷二萜7α-乙酰氧基-6β-羟基肉叶烯酮及其半合成类似物的抗癌作用：一种计算机模拟计算方法。
Molecules. 2024 Apr 16;29(8):1807. doi: 10.3390/molecules29081807.
9
Exploring the Anticancer Potential of Semisynthetic Derivatives of 7α-Acetoxy-6β-hydroxyroyleanone from sp.: An In Silico Approach.探索来自[具体植物名称]的7α-乙酰氧基-6β-羟基肉叶烯酮半合成衍生物的抗癌潜力：一种计算机模拟方法。
Int J Mol Sci. 2024 Apr 20;25(8):4529. doi: 10.3390/ijms25084529.
10
Preliminary Biological Activity Screening of spp. Extracts for the Search of Anticancer Lead Molecules.用于寻找抗癌先导分子的 spp. 提取物的初步生物活性筛选
Pharmaceuticals (Basel). 2021 Apr 23;14(5):402. doi: 10.3390/ph14050402.

引用本文的文献

1
Diterpenes Isolated from Three Different Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells.从三种不同物种中分离得到的二萜类化合物及其对妇科和胶质母细胞瘤癌细胞的抗增殖活性。
ACS Omega. 2024 Apr 8;9(16):18495-18504. doi: 10.1021/acsomega.4c00800. eCollection 2024 Apr 23.
2
Anticancer Effects of Abietane Diterpene 7α-Acetoxy-6β-hydroxyroyleanone from and Its Semi-Synthetic Analogs: An In Silico Computational Approach.来自[具体来源未给出]的枞烷二萜7α-乙酰氧基-6β-羟基肉叶烯酮及其半合成类似物的抗癌作用：一种计算机模拟计算方法。
Molecules. 2024 Apr 16;29(8):1807. doi: 10.3390/molecules29081807.
3

本文引用的文献

1
Insight the Biological Activities of Selected Abietane Diterpenes Isolated from spp.从 spp. 中分离出的几种松香烷二萜的生物活性研究
Biomolecules. 2020 Jan 28;10(2):194. doi: 10.3390/biom10020194.
2
Anti-Migratory and Pro-Apoptotic Properties of Parvifloron D on Triple-Negative Breast Cancer Cells.Parvifloron D 对三阴性乳腺癌细胞的抗迁移和促凋亡作用。
Biomolecules. 2020 Jan 19;10(1):158. doi: 10.3390/biom10010158.
3
An Evaluation of the DNA-Protective Effects of Extracts from L. Plants Derived from Culture Associated with Redox Balance and Other Biological Activities.
Biological Properties of Extracts Obtained from In Vitro Culture of in a Cell Model.
从体外培养的 细胞模型中提取的提取物的生物学特性。
Int J Mol Sci. 2024 Jan 15;25(2):1043. doi: 10.3390/ijms25021043.
4
Coleon U, Isolated from Codd., Decreases P-Glycoprotein Activity Due to Mitochondrial Inhibition.从科德氏植物中分离得到的科列昂U因线粒体抑制作用而降低P-糖蛋白活性。
Pharmaceutics. 2023 Jul 12;15(7):1942. doi: 10.3390/pharmaceutics15071942.
5
Parvifloron D-based potential therapy for glioblastoma: Inducing apoptosis the mitochondria dependent pathway.基于小花素D的胶质母细胞瘤潜在疗法：诱导线粒体依赖途径的细胞凋亡。
Front Pharmacol. 2022 Oct 12;13:1006832. doi: 10.3389/fphar.2022.1006832. eCollection 2022.
6
An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Codd. In Vitro and In Silico.从 Codd 中分离出的二萜的新型生物学特性的评价：体外和计算机模拟。
Cells. 2022 Oct 15;11(20):3243. doi: 10.3390/cells11203243.
7
Anticancer Properties of -Derived Phytochemicals Inducing Apoptosis via Mitochondrial Pathway.- 来源植物次生代谢物的抗癌特性通过线粒体通路诱导细胞凋亡。
Int J Mol Sci. 2022 Oct 1;23(19):11653. doi: 10.3390/ijms231911653.
8
Phytochemical Study and Antiglioblastoma Activity Assessment of (Forssk.) Schweinf. ex Sprenger var. hadiensis Stems.（福司氏）沙戟茎的植物化学研究及抗神经胶质瘤活性评估。
Molecules. 2022 Jun 14;27(12):3813. doi: 10.3390/molecules27123813.
9
C--Abietane and Three Abietane Diterpenoids from Leaves as P-Glycoprotein Modulators.来自树叶的贝壳杉烷及三种贝壳杉烷二萜类化合物作为P-糖蛋白调节剂
ACS Med Chem Lett. 2022 Mar 11;13(4):674-680. doi: 10.1021/acsmedchemlett.1c00711. eCollection 2022 Apr 14.
10
Hidden in Plants-A Review of the Anticancer Potential of the Solanaceae Family in In Vitro and In Vivo Studies.植物中的奥秘——茄科植物在体外和体内研究中抗癌潜力的综述
Cancers (Basel). 2022 Mar 11;14(6):1455. doi: 10.3390/cancers14061455.
评价与氧化还原平衡和其他生物活性相关的培养物衍生的 L. 植物提取物的 DNA 保护作用。
Oxid Med Cell Longev. 2019 Oct 16;2019:9165784. doi: 10.1155/2019/9165784. eCollection 2019.
4
Development and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells.小花糖芥素白蛋白纳米粒对表皮生长因子受体过表达的胰腺癌细胞增强细胞毒性潜力的研究进展及作用机制洞察
Cancers (Basel). 2019 Nov 5;11(11):1733. doi: 10.3390/cancers11111733.
5
Parvifloron D from : Cytotoxicity Screening of spp. Extracts.从：植物提取物的细胞毒性筛选。
Biomolecules. 2019 Oct 17;9(10):616. doi: 10.3390/biom9100616.
6
Cytotoxic Activity of Royleanone Diterpenes from Benth.来自Benth.的罗伊莱酮二萜类化合物的细胞毒性活性
ACS Omega. 2019 May 2;4(5):8094-8103. doi: 10.1021/acsomega.9b00512. eCollection 2019 May 31.
7
Transformed Root Extract Has Potent Anticancer Activity in Human Leukemia and Lung Adenocarcinoma Cell Lines.转化根提取物在人白血病和肺腺癌细胞系中具有很强的抗癌活性。
Oxid Med Cell Longev. 2018 Dec 9;2018:8198652. doi: 10.1155/2018/8198652. eCollection 2018.
8
Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells.由睡菜提取的体外和体内植物提取物诱导人癌细胞凋亡
Cytotechnology. 2019 Feb;71(1):165-180. doi: 10.1007/s10616-018-0274-9. Epub 2019 Jan 4.
9
Development of Parvifloron D-loaded Smart Nanoparticles to Target Pancreatic Cancer.负载小花素D的智能纳米颗粒用于靶向胰腺癌的研发。
Pharmaceutics. 2018 Nov 4;10(4):216. doi: 10.3390/pharmaceutics10040216.
10
An In Vitro Estimation of the Cytotoxicity and Genotoxicity of Root Extract from L. Overexpressing AtPAP1 against Different Cancer Cell Lines.过表达 AtPAP1 的 L. 根提取物的体外细胞毒性和遗传毒性评估及其对不同癌细胞系的作用。
Molecules. 2018 Aug 16;23(8):2049. doi: 10.3390/molecules23082049.