Kowalczyk Tomasz, Merecz-Sadowska Anna, Rijo Patricia, Mori Mattia, Hatziantoniou Sophia, Górski Karol, Szemraj Janusz, Piekarski Janusz, Śliwiński Tomasz, Bijak Michał, Sitarek Przemysław
Department of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland.
Department of Computer Science in Economics, University of Lodz, 90-214 Lodz, Poland.
Cancers (Basel). 2022 Mar 11;14(6):1455. doi: 10.3390/cancers14061455.
Many of the anticancer agents that are currently in use demonstrate severe side effects and encounter increasing resistance from the target cancer cells. Thus, despite significant advances in cancer therapy in recent decades, there is still a need to discover and develop new, alternative anticancer agents. The plant kingdom contains a range of phytochemicals that play important roles in the prevention and treatment of many diseases. The Solanaceae family is widely used in the treatment of various diseases, including cancer, due to its bioactive ingredient content. The purpose of this literature review is to highlight the antitumour activity of Solanaceae extracts-single isolated compounds and nanoparticles with extracts-and their synergistic effect with chemotherapeutic agents in various in vitro and in vivo cancer models. In addition, the biological properties of many plants of the Solanaceae family have not yet been investigated, which represents a challenge and an opportunity for future anticancer therapy.
目前正在使用的许多抗癌药物都表现出严重的副作用，并且面临着靶癌细胞越来越强的耐药性。因此，尽管近几十年来癌症治疗取得了重大进展，但仍然需要发现和开发新的替代抗癌药物。植物界含有一系列在许多疾病的预防和治疗中发挥重要作用的植物化学物质。茄科植物由于其生物活性成分的含量，被广泛用于治疗包括癌症在内的各种疾病。这篇文献综述的目的是强调茄科植物提取物（单一分离化合物以及提取物与纳米颗粒）在各种体外和体内癌症模型中的抗肿瘤活性，以及它们与化疗药物的协同作用。此外，许多茄科植物的生物学特性尚未得到研究，这对未来的抗癌治疗而言既是挑战也是机遇。
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