Sobczyk-Guzenda Anna, Boniecka Paulina, Laska-Lesniewicz Anna, Makowka Marcin, Szymanowski Hieronim
Institute of Materials Science and Engineering, Lodz University of Technology, Stefanowskiego 1/15 Str., 90-924 Lodz, Poland.
Materials (Basel). 2020 Jun 17;13(12):2736. doi: 10.3390/ma13122736.
Acrylate polymer-based bone cements constitute the most popular bonding agents used in regenerative surgery. Due to their inferior biocompatibility, however, these materials are often enriched with ceramic additives including hydroxyapatite (HAp). The aim of this paper was to perform a comparative study of the acrylate cements filled with different content (3-21%) of nano- and microscale hydroxyapatite. The work concerns a comparison of times and temperatures of the cross-linking reaction, as well as morphology, glass transition temperature, and principal mechanical properties of the resulting composites. Before being used as a filler, both HAp forms were subjected to an in-depth characterization of their morphology, specific surface area, pore size distribution, and wettability as well as chemical composition and structure. For that purpose, such analytical techniques as scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, tensiometry, Brunauer-Emmett-Teller surface area analysis, differential scanning calorimetry, Shore D hardness test, and Charpy impact test were used. The results indicated a drop of cross-linking temperature and an extension of setting time with the addition of µHAp. The µHAp-filled acrylate composites were characterized by a globular surface morphology, higher glass transition temperature, and lower hardness and impact strength compared to nHAp-filled materials. This relationship was evident at higher nHAp concentrations.
基于丙烯酸酯聚合物的骨水泥是再生手术中最常用的粘结剂。然而，由于其生物相容性较差，这些材料通常富含包括羟基磷灰石（HAp）在内的陶瓷添加剂。本文的目的是对填充有不同含量（3-21%）纳米和微米级羟基磷灰石的丙烯酸酯骨水泥进行对比研究。这项工作涉及交联反应的时间和温度的比较，以及所得复合材料的形态、玻璃化转变温度和主要力学性能的比较。在用作填料之前，对两种形式的HAp的形态、比表面积、孔径分布、润湿性以及化学成分和结构进行了深入表征。为此，使用了扫描电子显微镜、傅里叶变换红外光谱、X射线衍射、张力测量、布鲁诺尔-埃米特-泰勒表面积分析、差示扫描量热法、肖氏D硬度测试和夏比冲击测试等分析技术。结果表明，添加微尺度羟基磷灰石（µHAp）会降低交联温度并延长凝固时间。与填充纳米尺度羟基磷灰石（nHAp）的材料相比，填充µHAp的丙烯酸酯复合材料具有球状表面形态、更高的玻璃化转变温度以及更低的硬度和冲击强度。这种关系在较高的nHAp浓度下很明显。
