Department of Gastrointestinal Surgery Center and Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200025, P.R. China.
BMC Cancer. 2020 Jun 19;20(1):575. doi: 10.1186/s12885-020-07034-6.
Prognostic biomarkers remain a focus in breast cancer during last decades. More reliable predictors to adequately characterize the prognosis of breast cancer are essential. The 2'-5'-oligoadenylate synthetases (OAS), composing of OAS1, OAS2, OAS3, and OAS-like (OASL), are interferon (IFN)-induced antiviral enzymes, with their prognostic roles remain to be characterized.
Prognostic values of OAS family members were assessed by multiple public available resources.
High mRNA expression of OAS1 and OAS3 were correlated with worse prognosis for all breast cancer patients, whereas OAS2 was associated with favorable prognosis. The prognostic values of OAS family in different clinicopathologic subtypes were also characterized. In DNA methylation level, cg12560128 in OAS2, cg06800840 and cg26328872 in OASL showed significant prognostic values. The mRNA expression of OAS members signature in high/low risk overall survival groups was opposite to the high/low risk recurrence free survival groups. Neutrophil cell exhibited highest correlation with all OAS members in tumor immune infiltrating estimation.
This study provided new insight into the prognostic roles of OAS in breast cancer with potential mechanistic values.
在过去几十年中，预后生物标志物一直是乳腺癌研究的重点。寻找更可靠的预测因子来充分描述乳腺癌的预后至关重要。2'-5'-寡聚腺苷酸合成酶（OAS）由 OAS1、OAS2、OAS3 和 OAS 样（OASL）组成，是干扰素（IFN）诱导的抗病毒酶，其预后作用仍有待阐明。
通过多个公共可用资源评估 OAS 家族成员的预后价值。
OAS1 和 OAS3 的高 mRNA 表达与所有乳腺癌患者的预后不良相关，而 OAS2 与预后良好相关。OAS 家族在不同临床病理亚型中的预后价值也得到了描述。在 DNA 甲基化水平上，OAS2 中的 cg12560128、OASL 中的 cg06800840 和 cg26328872 具有显著的预后价值。OAS 成员在高/低风险总生存组中的 mRNA 表达与高/低风险无复发生存组相反。在肿瘤免疫浸润评估中，中性粒细胞与所有 OAS 成员的相关性最高。
本研究为 OAS 在乳腺癌中的预后作用提供了新的见解，并具有潜在的机制价值。
