Integrated PET/MR Imaging Centre, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Division of Radiotherapy, Department of Oncology Medicine, Taipei Veterans General Hospital, Taiwan.
Appl Radiat Isot. 2020 Sep;163:109219. doi: 10.1016/j.apradiso.2020.109219. Epub 2020 May 13.
One of the eligible criteria for patients to receive boron neutron capture therapy (BNCT) is based on the tumour-to-normal ratio (T/N) measured by FBPA-PET. However, there is no standard protocol for normal region-of-interested delineation. With comparison of contralateral cerebrum, our study revealed the consistency (p < 0.05) and high feasibility using the cerebellum as an alternative normal tissue baseline because of its homogeneous uptake. Following RECIST version 1.1, the standard-operating-procedure (SOP) for the BNCT fulfilled the expected tumour response and tumour shrinkage rate (p < 0.05). Our modified procedure can provide more precise information for BNCT within a reasonable time.
硼中子俘获治疗（BNCT）的患者入选标准之一是通过 FBPA-PET 测量肿瘤与正常组织的比值（T/N）。然而，对于正常感兴趣区域的勾画，目前尚无标准方案。与对侧大脑相比，本研究显示由于小脑摄取均匀，将小脑作为替代正常组织基线具有一致性（p<0.05）和较高的可行性。根据 RECIST 版本 1.1，BNCT 的标准操作程序（SOP）符合预期的肿瘤反应和肿瘤退缩率（p<0.05）。我们的改良方案可以在合理的时间内为 BNCT 提供更精确的信息。
