Institute of Pathogenic Biology, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China.
Department of Laboratory Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China.
Life Sci. 2020 Sep 1;256:117981. doi: 10.1016/j.lfs.2020.117981. Epub 2020 Jun 17.
Cervical cancer (CC) is regarded as the second serious threat to women's health worldwide; it's associated with certain viruses that are transmitted through sexual intercourse. Therefore, the pathogenesis of CC remains to be studied. The identified long non-coding RNAs (lncRNAs) as a key genomic product were found to be commonly dysregulated in CC and to exert significant effects in the initiation, migration, invasion and therapeutic response of CC. Therefore lncRNAs may be used as tumor suppressor genes or oncogenes to interact with DNA, RNA or proteins for the regulation of gene expression and cell signaling pathways. The relationship between single lncRNA and CC has been discovered. However, full-scale reviews on the lncRNAs function in CC are deficiency. In this review, we describe the recent reports on the dysregulated patterns regulation of lncRNAs in CC. We also conclude the recent advances on biologic functions and molecular regulation mechanism and potential clinical application of lncRNAs in CC.
宫颈癌（CC）被认为是全球女性健康的第二大严重威胁；它与某些通过性交传播的病毒有关。因此，CC 的发病机制仍有待研究。已确定的长非编码 RNA（lncRNA）作为一种关键的基因组产物，在 CC 中普遍失调，并在 CC 的起始、迁移、侵袭和治疗反应中发挥重要作用。因此，lncRNA 可能被用作肿瘤抑制基因或癌基因，与 DNA、RNA 或蛋白质相互作用，以调节基因表达和细胞信号通路。已经发现了单个 lncRNA 与 CC 之间的关系。然而，全面综述 lncRNA 在 CC 中的功能还很缺乏。在这篇综述中，我们描述了 lncRNA 在 CC 中失调模式的最新报道。我们还总结了 lncRNA 在 CC 中的生物学功能和分子调控机制以及潜在的临床应用的最新进展。
