细胞重编程与衰老和再生中的衰老之间的串扰。

The crosstalk between cellular reprogramming and senescence in aging and regeneration.

机构信息

Cellular Plasticity and Disease Modelling, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France.

出版信息

Exp Gerontol. 2020 Sep;138:111005. doi: 10.1016/j.exger.2020.111005. Epub 2020 Jun 17.

DOI:10.1016/j.exger.2020.111005

PMID:32561400

Abstract

Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue regeneration and rejuvenation. Here we review recent studies on the interplay between cellular senescence and reprogramming. We discuss how both strategies could impact aging process and the possibility of combine them for more efficient regeneration and rejuvenation.

摘要

衰老是与再生能力下降和慢性疾病风险增加有关。现在有令人信服的证据表明，衰老过程是可逆的。除了代谢修饰和系统因素外，衰老消除和细胞重编程都对组织再生和年轻化有有益的影响。在这里，我们回顾了细胞衰老与重编程之间相互作用的最新研究。我们讨论了这两种策略如何影响衰老过程，以及将它们结合起来以实现更有效的再生和年轻化的可能性。