University of Colorado School of Medicine, Anschutz Medical Campus, Department of Pediatrics, Section of Developmental Biology, 12801 E 17th Avenue, Aurora, CO 80045, USA.
Department of Molecular Life Sciences, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Development. 2020 Jun 19;147(12):dev175059. doi: 10.1242/dev.175059.
The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo. Despite this central role in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM-derived tissues. Finally, we discuss the development of seemingly disparate organ systems that share a common LPM origin.
侧板中胚层（LPM）形成祖细胞，这些祖细胞构成了在脊椎动物胚胎发育过程中心脏和心血管系统、血液、肾脏、平滑肌谱系和肢体骨骼。尽管在发育和进化中具有核心作用，但由于其谱系复杂性和缺乏简洁的遗传定义，LPM 仍然难以研究和描绘。在这里，我们概述了控制 LPM 特化、组织、细胞命运以及推断的 LPM 衍生组织进化轨迹的过程。最后，我们讨论了看似不同的器官系统的发育，这些器官系统具有共同的 LPM 起源。
