中胚层的特化和多样化：从单细胞到新兴组织。
Mesoderm specification and diversification: from single cells to emergent tissues.
机构信息
The Novo Nordisk Foundation Center for Stem Cell Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA.
出版信息
Curr Opin Cell Biol. 2019 Dec;61:110-116. doi: 10.1016/j.ceb.2019.07.012. Epub 2019 Aug 30.
The three germ layers - mesoderm, endoderm and ectoderm - constituting the cellular blueprint for the tissues and organs that will form during embryonic development, are specified at gastrulation. Cells of mesodermal origin are the most abundant in the human body, representing a great variety of cell types, including the musculoskeletal system (bone, cartilage and muscle), cardiovascular system (heart, blood and blood vessels), as well as the connective tissues found throughout our bodies. A long-standing question pertains how this panoply of mesodermal cell types arises in a stereotypical fashion in time and space. This review discusses the events associated with mesoderm specification, highlighting the reconstruction of putative developmental trajectories facilitated by recent single-cell 'omic' data. We will also discuss the potential of emergent organoid systems to emulate and interrogate the dynamics of lineage specification at cellular resolution.
三个胚层——中胚层、内胚层和外胚层——构成了胚胎发育过程中形成的组织和器官的细胞蓝图，在原肠胚形成时被指定。中胚层起源的细胞在人体中最为丰富，代表了多种细胞类型，包括骨骼肌肉系统（骨、软骨和肌肉）、心血管系统（心脏、血液和血管）以及我们身体各处的结缔组织。一个长期存在的问题是，这种多样化的中胚层细胞类型是如何在时间和空间上以典型的方式出现的。这篇综述讨论了与中胚层特化相关的事件，强调了最近单细胞“组学”数据所促成的对假定发育轨迹的重建。我们还将讨论新兴类器官系统在细胞分辨率下模拟和探究谱系特化动态的潜力。
Zotero 插件