糖皮质激素对肾上腺皮质的抑制作用：犬骨科手术前单次肌内注射倍他米松长效制剂与安慰剂的效果比较
Adrenocortical suppression by a glucocorticoid: effect of a single i.m. injection of betamethasone depot versus placebo given prior to orthopaedic surgery in dogs.
作者信息
Mbugua S W, Skoglund L A, Djøseland O, Løkken P
出版信息
Acta Vet Scand. 1988;29(3-4):415-9. doi: 10.1186/BF03548637.
Abstract
The suppression of the endogenous serum Cortisol level by a single i. m. injection of 3 mg betamethasone depot (Celeston Chronodose) prior to orthopaedic surgical interventions on the forelimbs of 8 dogs was studied in a placebo–controlled cross–over trial. Compared to placebo the endogenous serum Cortisol level was significantly (p < 0.05) reduced for a period of 4 days, and then returned to the pre–operative range. During the 28–day observation period after each surgical intervention no impairment of wound healing, bleeding episodes or side–effects which could be attributed to the glucocorticoid, was seen.
摘要
在一项安慰剂对照的交叉试验中，研究了在8只狗的前肢进行骨科手术干预前，单次肌肉注射3毫克倍他米松长效制剂（塞来松缓释剂）对内源性血清皮质醇水平的抑制作用。与安慰剂相比，内源性血清皮质醇水平在4天内显著降低（p < 0.05），然后恢复到术前范围。在每次手术干预后的28天观察期内，未发现伤口愈合受损、出血事件或可归因于糖皮质激素的副作用。
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