Mbugua S W, Skoglund L A, Skjelbred P, Løkken P
Acta Vet Scand. 1988;29(1):43-9. doi: 10.1186/BF03548390.
The capability of a single i.m. injection of betamethasone (Celeston Chronodose®) to modulate a post-operative course was investigated in a placebo-controlled crossover trial with 8 dogs. Two »identical« soft tissue/bone operations were performed on the forelimbs of each animal with an interval of 28 days, to allow a paired comparison of the inflammatory signs and healing process. Significantly less swelling, but not less pain and limping, was observed when the glucocorticoid was administered. No adverse effect of the glucocorticoid was seen on wound and bone healing. The present experimental model is suggested useful for evaluation of anti-inflammatory drug effects in accidental trauma and orthopaedic surgery.
在一项针对8只犬的安慰剂对照交叉试验中，研究了单次肌内注射倍他米松（Celeston Chronodose®）对术后病程的调节作用。对每只动物的前肢进行两次“相同”的软组织/骨手术，间隔28天，以便对炎症体征和愈合过程进行配对比较。给予糖皮质激素时，肿胀明显减轻，但疼痛和跛行并未减轻。未观察到糖皮质激素对伤口和骨愈合有不良影响。本实验模型被认为可用于评估抗炎药物在意外创伤和骨科手术中的作用。
