Center for Comparative Medicine, Beckman Research Institute of the City of Hope, 1500 East Duarte Rd, Duarte, CA, 91010, USA.
Nitric Oxide. 2020 Sep 1;102:39-41. doi: 10.1016/j.niox.2020.06.002. Epub 2020 Jun 17.
COVID-19 is a severe pandemic which has caused a devastating amount of loss in lives around the world, and yet we still don't know how to appropriately treat this disease. We know very little about the pathogenesis of SARS-CoV-2, the virus which induces the COVID-19. However, COVID-19 does share many similar symptoms with SARS and influenza. Previous scientific discoveries learned from lab animal models and clinical practices shed light on possible pathogenic mechanisms in COVID-19. In the past decades, accumulated scientific findings confirmed the pathogenic role of free radicals damage in respiratory virus infection. Astonishingly very few medical professionals mention the crucial role of free radical damage in COVID-19. This hypothesis aims to summarize the crucial pathogenic role of free radical damage in respiratory virus induced pneumonia and suggest an antioxidative therapeutic strategy for COVID-19.
COVID-19 是一种严重的大流行病，它在全球范围内造成了大量生命损失，但我们仍然不知道如何恰当地治疗这种疾病。我们对引发 COVID-19 的 SARS-CoV-2 病毒的发病机制知之甚少。然而，COVID-19 确实与 SARS 和流感有许多相似的症状。从实验室动物模型和临床实践中获得的先前科学发现揭示了 COVID-19 中可能的发病机制。在过去的几十年中，积累的科学发现证实了自由基损伤在呼吸道病毒感染中的致病作用。令人惊讶的是，很少有医学专业人员提到自由基损伤在 COVID-19 中的关键作用。本假说旨在总结自由基损伤在呼吸道病毒引起的肺炎中的关键致病作用，并为 COVID-19 提出抗氧化治疗策略。
