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中国大陆首例利奈唑胺致儿童牙齿着色。

The first case of teeth discoloration induced by linezolid in children in China Mainland.

机构信息

Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.

Department of Traumatic Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.

出版信息

J Infect Chemother. 2020 Oct;26(10):1062-1065. doi: 10.1016/j.jiac.2020.05.010. Epub 2020 Jun 17.

DOI:10.1016/j.jiac.2020.05.010
PMID:32563555
Abstract

Linezolid is an oxazolidinone antimicrobial agent often used to treat multidrug-resistant Gram-positive bacterial infections. The common adverse reactions of linezolid are diarrhea, nausea, headache and bone marrow suppression, and so on. Here, we report the first case of teeth discoloration induced by linezolid linked with extrinsic discoloration in China Mainland. This case report highlights a rare adverse reactions of a commonly used antibiotic.

摘要

利奈唑胺是一种恶唑烷酮类抗菌药物,常被用于治疗多种耐药革兰阳性菌感染。利奈唑胺的常见不良反应包括腹泻、恶心、头痛和骨髓抑制等。在这里,我们报告了中国大陆首例与外源性着色相关的利奈唑胺引起的牙齿着色病例。本病例报告强调了一种常用抗生素的罕见不良反应。

相似文献

1
The first case of teeth discoloration induced by linezolid in children in China Mainland.中国大陆首例利奈唑胺致儿童牙齿着色。
J Infect Chemother. 2020 Oct;26(10):1062-1065. doi: 10.1016/j.jiac.2020.05.010. Epub 2020 Jun 17.
2
Safety and tolerability of linezolid in children.利奈唑胺在儿童中的安全性和耐受性。
Pediatr Infect Dis J. 2003 Sep;22(9 Suppl):S193-200. doi: 10.1097/01.inf.0000087022.58089.d8.
3
Tedizolid: a new oxazolidinone antimicrobial.特地唑胺:一种新型恶唑烷酮类抗菌药物。
Am J Health Syst Pharm. 2014 Apr 15;71(8):621-33. doi: 10.2146/ajhp130482.
4
Linezolid: in infants and children with severe Gram-positive infections.利奈唑胺:用于患有严重革兰氏阳性菌感染的婴幼儿。
Paediatr Drugs. 2003;5(6):419-29; discussion 430-1. doi: 10.2165/00128072-200305060-00009.
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Drug-drug interactions and safety of linezolid, tedizolid, and other oxazolidinones.利奈唑胺、替地唑胺及其他恶唑烷酮类药物的药物相互作用与安全性
Expert Opin Drug Metab Toxicol. 2015;11(12):1849-59. doi: 10.1517/17425255.2015.1098617. Epub 2015 Oct 12.
6
Linezolid.利奈唑胺
Indian Pediatr. 2004 Nov;41(11):1129-32.
7
Tooth discoloration after treatment with linezolid.利奈唑胺治疗后的牙齿变色。
Pharmacotherapy. 2003 May;23(5):682-5. doi: 10.1592/phco.23.5.682.32207.
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Linezolid for the treatment of adults with bone and joint infections.利奈唑胺用于治疗成人骨与关节感染。
Int J Antimicrob Agents. 2007 Mar;29(3):233-9. doi: 10.1016/j.ijantimicag.2006.08.030. Epub 2007 Jan 3.
9
Early lactic acidosis associated with linezolid therapy in paediatric patients.儿童患者接受利奈唑胺治疗后出现早期乳酸酸中毒。
Int J Antimicrob Agents. 2014 Oct;44(4):334-6. doi: 10.1016/j.ijantimicag.2014.06.017. Epub 2014 Aug 9.
10
Clinical experience with linezolid in infants and children.利奈唑胺在婴儿和儿童中的临床经验。
J Antimicrob Chemother. 2011 May;66 Suppl 4:iv23-iv41. doi: 10.1093/jac/dkr074.

引用本文的文献

1
Case Report: A case study and literature review on teeth discoloration caused by linezolid with the shortest incubation period in a pediatric patient.病例报告:关于利奈唑胺导致一名儿科患者牙齿变色且潜伏期最短的病例研究及文献综述。
Front Pediatr. 2024 Oct 15;12:1440322. doi: 10.3389/fped.2024.1440322. eCollection 2024.
2
Two Cases of Children With Black Hairy Tongue and Tooth Discoloration Caused by Antibacterial Agents.两例抗菌药物所致儿童黑毛舌和牙齿变色病例
Cureus. 2024 Apr 15;16(4):e58354. doi: 10.7759/cureus.58354. eCollection 2024 Apr.
3
Drug-induced tooth discoloration: An analysis of the US food and drug administration adverse event reporting system.
药物性牙齿变色:对美国食品药品监督管理局不良事件报告系统的分析
Front Pharmacol. 2023 Apr 13;14:1161728. doi: 10.3389/fphar.2023.1161728. eCollection 2023.