Le-le Sun, Qun Zhao, Lei Qi, Xiangwei Meng, Jigang Si
Department of Pharmacy, Binzhou Medical University Affiliated Zibo Central Hospital, Zibo, Shandong, China.
Department of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao, China.
Front Pediatr. 2024 Oct 15;12:1440322. doi: 10.3389/fped.2024.1440322. eCollection 2024.
When it comes to the adverse reactions of linezolid, people always call to mind primarily nausea, vomiting, bone marrow suppression, and so on. Few people are aware of the rare adverse reaction of teeth discoloration.
We describe the case of a child affected by bacterial meningitis. After admission, a combination of ceftriaxone and linezolid was administered for anti-infection, and dexamethasone was used to inhibit inflammatory reactions. On the 5th day of treatment with linezolid, the child's teeth appeared brownish color and could not be removed with normal oral hygiene. Upon reviewing the drug instructions and literature, it was found that the discoloration of teeth is a rare adverse reaction of linezolid, which is pseudo discoloration. After stopping the medication for 28 days or up to 5 months, the normal color can be restored. There is no significant impact on the life of the patient, therefore, continue to use linezolid to complete the anti-infection course.
After 14 days of anti-infection treatment, the inflammatory indicators of the child decreased to normal, and the condition was close to recovery before discharge. After stopping the medication for 28 days, the color of the teeth returned to normal.
This rare adverse reaction sheds light on a previously unreported side effect of this widely used antibiotic. In our case, the discoloration of the teeth occurred earlier, updating the latent period of the adverse reaction.
说到利奈唑胺的不良反应，人们首先想到的总是恶心、呕吐、骨髓抑制等。很少有人意识到牙齿变色这种罕见的不良反应。
我们描述了一名患有细菌性脑膜炎儿童的病例。入院后，给予头孢曲松和利奈唑胺联合抗感染治疗，并使用地塞米松抑制炎症反应。在使用利奈唑胺治疗的第5天，患儿牙齿出现褐色，通过正常口腔清洁无法去除。查阅药品说明书及文献发现，牙齿变色是利奈唑胺罕见的不良反应，属于假性变色。停药28天或长达5个月后，牙齿颜色可恢复正常。对患者生活无明显影响，因此，继续使用利奈唑胺完成抗感染疗程。
经过14天的抗感染治疗，患儿炎症指标降至正常，出院前病情接近痊愈。停药28天后，牙齿颜色恢复正常。
这种罕见的不良反应揭示了这种广泛使用的抗生素以前未报道的副作用。在我们的病例中，牙齿变色出现得更早，更新了不良反应的潜伏期。
