The Houston Methodist Research Institute, Houston, Texas, USA,
Department of Surgery, The Houston Methodist Hospital, Houston, Texas, USA,
Int Arch Allergy Immunol. 2020;181(8):629-634. doi: 10.1159/000508560. Epub 2020 Jun 19.
The difference between the female and male immune response to COVID-19 infection, and infections in general, is multifactorial. The well-known determiners of the immune response, such as X and Y chromosomes, sex hormones, and microbiota, are functionally interconnected and influence each other in shaping the organism's immunity. We focus our commentary on the interplay between the genetic sex and mitochondria and how this may affect a sex-dependent immune response in COVID-19 infection. Realizing the existence of these interactions may help in designing novel methods or fine-tuning the existing and routine therapies to fight COVID-19 and other infections.
女性和男性对 COVID-19 感染及一般感染的免疫反应存在差异，其原因是多方面的。众所周知，决定免疫反应的因素，如 X 和 Y 染色体、性激素和微生物组，在功能上是相互关联的，并相互影响，从而塑造了机体的免疫力。我们的评论集中在遗传性别和线粒体之间的相互作用上，以及这如何影响 COVID-19 感染中的性别依赖性免疫反应。认识到这些相互作用的存在，可能有助于设计新的方法，或微调现有的常规疗法，以对抗 COVID-19 和其他感染。
