中年饮酒与纵向脑萎缩：PREVENT-Dementia 研究。
Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study.
机构信息
Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Nuns Moor Road, Newcastle upon Tyne, NE4 5PL, UK.
Department of Psychiatry, University of Cambridge, Level E4 Cambridge Biomedical Campus, Box 189, Cambridge, CB2 0SP, UK.
出版信息
J Neurol. 2020 Nov;267(11):3282-3286. doi: 10.1007/s00415-020-10000-8. Epub 2020 Jun 20.
BACKGROUND AND AIMS
Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects.
METHODS
A sample of 162 subjects (aged 40-59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox, and change in hippocampal volume from segmentation in SPM.
RESULTS
Controlling for age and sex, there were no significant associations of either total brain, ventricular, or hippocampal volume change with alcohol consumption. Adjusting for lifestyle, demographic and vascular risk factors did not alter this.
CONCLUSIONS
We did not find any evidence of influence of alcohol consumption on changes in brain volume over a 2-year period in 40-60-year-olds.
背景与目的
目前对于轻中度饮酒与戒酒相比是否具有神经保护作用尚未达成共识。在这项研究中，我们调查了中年受试者中自我报告的饮酒与 2 年内脑容量变化之间的关系。
方法
预防痴呆症计划中的 162 名受试者（基线时年龄为 40-59 岁）在两次不同的时间接受 MRI 扫描（平均间隔 734 天；SD 42 天）。我们使用 FSL Siena 工具包测量了脑萎缩的纵向速度，并使用 SPM 中的分割来测量海马体体积的变化。
结果
控制年龄和性别后，总脑、脑室或海马体体积变化与饮酒量之间没有显著关联。调整生活方式、人口统计学和血管危险因素后，结果仍然不变。
结论
我们没有发现 40-60 岁人群中饮酒对脑容量变化的影响。
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