The Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
The Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; The Department of Neurology, Columbia University, New York, NY, USA; National and Kapodistrian University of Athens Medical School, Athens, Greece.
Clin Nutr. 2014 Aug;33(4):662-7. doi: 10.1016/j.clnu.2013.08.004. Epub 2013 Aug 21.
BACKGROUND & AIMS: Evidence suggests that consuming light-to-moderate amounts of alcohol reduces the risk of dementia and is associated better cognitive function and less cardiovascular disease, relative to those consuming no or heavy alcohol. There are only minimal data on the association between alcohol and brain magnetic resonance imaging (MRI) markers. This study aimed to examine the association between alcohol and brain structure measured with MRI.
In this cross-sectional study, high-resolution structural MRI was collected on 589 multi-ethnic community residents of New York aged ≥65 with available alcohol intake assessments via a food frequency questionnaire. Total brain volume (TBV), white matter hyperintensity volume (WMHV), and presence of infarcts were derived from MRI scans with established methods. We examined the association of alcohol intake with these imaging markers using regression models adjusted for demographic, clinical, and vascular risk factors.
Compared to non-drinking, light-to-moderate total alcohol (b = 0.007, p = 0.04) or wine (b = 0.008, p = 0.05) intake, but not beer or liquor intake, was associated with larger TBV. Further analysis showed a dose-response association between alcohol (p-trend = 0.03) or wine (p-trend = 0.006) and TBV. Overall, alcohol intake was not associated with WMHV or brain infarcts.
Our study suggests that among older adults in the community, light-to-moderate alcohol intake, in particular wine, is associated with larger TBV. These findings suggest that light to moderate alcohol consumption is potentially beneficial for brain aging, but replication is needed.
有证据表明，适量饮酒可降低痴呆风险，与不饮酒或大量饮酒者相比，适量饮酒者的认知功能更好，心血管疾病更少。关于饮酒与脑磁共振成像（MRI）标志物之间的关联，仅有极少数据。本研究旨在探讨通过 MRI 测量的酒精与大脑结构之间的关系。
在这项横断面研究中，对 589 名年龄在 65 岁及以上的纽约多民族社区居民进行了高分辨率结构 MRI 采集，这些居民通过食物频率问卷提供了可获得的饮酒量评估。使用已建立的方法从 MRI 扫描中得出总脑容量（TBV）、脑白质高信号体积（WMHV）和梗死的存在。我们使用回归模型，根据人口统计学、临床和血管危险因素调整了饮酒量与这些影像学标志物的关系。
与不饮酒相比，轻至中度总酒精（b = 0.007，p = 0.04）或葡萄酒（b = 0.008，p = 0.05）的摄入与更大的 TBV 相关，但啤酒或白酒的摄入与 TBV 无关。进一步的分析显示，酒精（p 趋势 = 0.03）或葡萄酒（p 趋势 = 0.006）与 TBV 之间存在剂量反应关系。总体而言，饮酒量与 WMHV 或脑梗死无关。
我们的研究表明，在社区中的老年人中，轻至中度饮酒，特别是葡萄酒，与更大的 TBV 相关。这些发现表明，轻度至中度饮酒可能对大脑衰老有益，但需要进一步的研究证实。
