[Efficacy of esophageal cancer screening program on population at high risk: a survey carried out in people aged 40-69 years in Yangzhong, Jiangsu province].

To understand the incidence of esophageal cancer in population at high risk in Yangzhong of Jiangsu province. Cluster random sampling method was conducted to select several natural villages from the high risk area of esophageal cancer in Yangzhong during 2011-2017. Local residents aged 40-69 years were selected as the target population and a total of 14 687 persons were diagnosed esophageal cancer by endoscopy and pathology. Precancerous lesions were detected in 341 persons, with the detection rate as 2.32 (341/14 687). Among them, there were 234 (1.59) cases with mild and 107 (0.73) cases with moderate esophageal hyperplasia. There were 77 positive cases with esophageal hyperplasia and the detection rate was 0.52. Among these positive cases, 41 showed severe esophageal hyperplasia/carcinoma in situ (0.28), with another 19 as early esophageal cancer (0.13) and 17 with invasive carcinoma (0.12). The overall early detection rate of positivity through active screening was 77.92 (60/77), with trends of upwarding and then downwarding. The detection rate of esophageal lesions in men was higher than that in women (<0.05), but without significant gender specific differences seen in the detection rates of early esophageal cancer or invasive carcinoma (>0.05). The detection rates of all lesions other than invasive carcinoma, gradually increased with age (<0.05). The detection rate of invasive carcinoma reached the highest (0.39, 10/2 547) in the age group of 60-years and slightly decreased in the age group of 65-years old. Considerable numbers of patients with cancer and precancerous lesions in groups at high-risk can be found through the screening program for esophageal cancer, suggesting that the screening program is of great significance in improving the survival rate and quality of life. Attention should be paid to men, with elderly groups in particular, at high-risk in order to increase the detection rate of early cases.