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台湾皮肤科医学会特应性皮炎治疗共识:2020 年更新版。

Taiwanese Dermatological Association consensus for the management of atopic dermatitis: A 2020 update.

机构信息

Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.

出版信息

J Formos Med Assoc. 2021 Jan;120(1 Pt 2):429-442. doi: 10.1016/j.jfma.2020.06.008. Epub 2020 Jun 19.

Abstract

BACKGROUND/PURPOSE: Atopic dermatitis (AD) is a chronic inflammatory disease commonly seen in children and increasingly recognized in adults. With recent advances in the therapeutic development for AD, the Taiwanese Dermatological Association (TDA) established a committee to update the consensus for AD management in Taiwan. This report describes the 2020 updated consensus for the management of AD.

METHODS

A panel of 11 core members was convened to review and discuss aspects of AD management and draft recommendation during the first two meetings. The 2015 TDA consensus and the 2017 European guideline, along with recent peer-reviewed articles, serve as the foundation for the update. In the third meeting, AD expert dermatologists selected on a national scale were invited to vote on the final statements. A total of 27 dermatologists attended the final meeting. The consensus was achieved when ratings of 7-9 (out of a total score of 9) accounted for ≥ 75% of the total votes.

RESULTS

Consensus was achieved on the therapeutic options for AD by lines of treatment. A treatment algorithm was presented to illustrate the place of each modality in terms of basic care, acute disease control, and maintenance therapy. Special considerations for the pediatric population, as well as for women during pregnancy and lactation, are discussed.

CONCLUSION

Topical corticosteroids with long-term emollient-based therapies remain the cornerstone of AD treatment. Systemic treatments are indicated when topical therapies and phototherapy fail to control the disease. The recent approval of dupilumab and emerging targeted therapies are expected to bring significant clinical benefit for patients whose disease is inadequately managed by existing options.

摘要

背景/目的:特应性皮炎(AD)是一种常见于儿童的慢性炎症性疾病,在成人中也越来越常见。随着 AD 治疗方法的不断发展,台湾皮肤科医学会(TDA)成立了一个委员会,以更新台湾 AD 管理的共识。本报告描述了 2020 年更新的 AD 管理共识。

方法

召集了 11 名核心成员组成一个小组,在头两次会议上审查和讨论 AD 管理的各个方面,并起草建议。2015 年 TDA 共识和 2017 年欧洲指南,以及最近的同行评议文章,为本次更新提供了基础。在第三次会议上,邀请了全国范围内选择的 AD 专家皮肤科医生对最终声明进行投票。共有 27 名皮肤科医生参加了最后一次会议。当总分 9 分中 7-9 分(总投票数的 75%以上)的评分占比达到≥75%时,共识达成。

结果

通过治疗线达成了 AD 治疗选择的共识。提出了一个治疗算法,说明每种方法在基础护理、急性疾病控制和维持治疗方面的地位。讨论了儿科人群以及妊娠和哺乳期妇女的特殊考虑因素。

结论

长期保湿剂基础上的外用皮质类固醇仍然是 AD 治疗的基石。当外用治疗和光疗未能控制疾病时,需要使用全身治疗。达必妥和新兴的靶向治疗的最近批准预计将为现有治疗方案不能充分控制疾病的患者带来显著的临床获益。

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