Health Service & Population Research department, Institute of Psychiatry Psychology and Neuroscience, London, UK.
ESRC Centre for Society and Mental Health, King's College London, London, UK.
BMJ Open. 2020 Jun 21;10(6):e039004. doi: 10.1136/bmjopen-2020-039004.
There are few robust and directly comparable studies of the epidemiology of psychotic disorders in the Global South. INTREPID II is designed to investigate variations in untreated psychotic disorders in the Global South in (1) incidence and presentation (2) 2-year course and outcome, (3) help-seeking and impact, and (4) physical health.
INTREPID II is a programme of research incorporating incidence, case-control and cohort studies of psychoses in contiguous urban and rural areas in India, Nigeria and Trinidad. In each country, the target samples are 240 untreated cases with a psychotic disorder, 240 age-matched, sex-matched and neighbourhood-matched controls, and 240 relatives or caregivers. Participants will be followed, in the first instance, for 2 years. In each setting, we have developed and are employing comprehensive case-finding methods to ensure cohorts are representative of the target populations. Using methods developed during pilot work, extensive data are being collected at baseline and 2-year follow-up across several domains: clinical, social, help-seeking and impact, and biological.
Informed consent is sought, and participants are free to withdraw from the study at any time. Participants are referred to mental health services if not already in contact with these and emergency treatment arranged where necessary. All data collected are confidential, except when a participant presents a serious risk to either themselves or others. This programme has been approved by ethical review boards at all participating centres. Findings will be disseminated through international conferences, publications in international journals, and through local events for key stakeholders.
在全球南方，很少有针对精神病流行病学的稳健且可直接比较的研究。INTREPID II 旨在调查全球南方未治疗的精神病障碍在（1）发病率和表现、（2）2 年病程和结局、（3）寻求帮助和影响，以及（4）身体健康方面的差异。
INTREPID II 是一项包含发病率、病例对照和队列研究的研究计划，涉及印度、尼日利亚和特立尼达的连续城市和农村地区的精神病。在每个国家，目标样本是 240 例未经治疗的精神病患者、240 例年龄、性别和邻里匹配的对照者，以及 240 名亲属或护理人员。参与者将首先随访 2 年。在每个环境中，我们已经开发并正在使用综合病例发现方法来确保队列代表目标人群。利用试点工作中开发的方法，正在在多个领域收集基线和 2 年随访时的广泛数据：临床、社会、寻求帮助和影响以及生物学。
已征得知情同意，参与者可随时退出研究。如果参与者尚未与这些服务接触，将转介到心理健康服务机构，并在必要时安排紧急治疗。除非参与者对自己或他人构成严重威胁，否则收集的所有数据均保密。该计划已获得所有参与中心的伦理审查委员会的批准。研究结果将通过国际会议、国际期刊发表的文章以及为主要利益相关者举办的当地活动进行传播。
