补骨脂素涂剂联合长波紫外线治疗斑秃的疗效——我们在国家皮肤中心的经验
Effectiveness of Paint Psoralen and Ultraviolet-A in Alopecia Areata - Our Experience in the National Skin Center.
作者信息
Tan Lucinda Siyun, Chan Melissa Mei Hsia, Tan Daryl Jian An, Lee Joyce Siong See, Chong Wei-Sheng
机构信息
Department of Dermatology, National Skin Centre, Singapore.
MD Programme, Duke-NUS Medical School, Singapore.
出版信息
Indian J Dermatol. 2020 May-Jun;65(3):199-203. doi: 10.4103/ijd.IJD_400_18.
BACKGROUND
Alopecia areata (AA) is usually a benign cause of patchy hair loss that often resolves within a few weeks to months. Most treatment modalities are ineffective in the treatment of severe AA. The use of paint psoralen and ultraviolet-A (PUVA) in the treatment of patients with severe forms of AA has been reported in the literature.
AIMS AND OBJECTIVE
The aim of this study was to evaluate the effectiveness of paint PUVA therapy in the treatment of AA in Singapore.
MATERIALS AND METHODS
We performed a 10-year retrospective analysis of patients who underwent paint PUVA for AA. We evaluated patient demographics and treatment outcomes in the form of percentage change in baseline severity of alopecia tool score and final amount of hair regrowth and relapse rate.
RESULTS
Ten patients were included in this study. With paint PUVA therapy, significant hair regrowth was seen in six patients. Paint PUVA therapy in our study showed minimal side effects.
CONCLUSION
PUVA gives fair response in AA in a reasonable time as per our center's experience in Singapore.
背景
斑秃（AA）通常是导致斑片状脱发的良性病因，常可在数周或数月内自行缓解。大多数治疗方法对重度斑秃无效。文献报道了使用补骨脂素与紫外线A（PUVA）联合治疗重度斑秃患者的情况。
目的
本研究旨在评估在新加坡采用PUVA涂抹疗法治疗斑秃的有效性。
材料与方法
我们对接受PUVA涂抹疗法治疗斑秃的患者进行了为期10年的回顾性分析。我们以斑秃工具评分基线严重程度的百分比变化、最终毛发再生量和复发率的形式评估患者的人口统计学特征和治疗结果。
结果
本研究纳入了10例患者。采用PUVA涂抹疗法后，6例患者出现了显著的毛发再生。我们研究中的PUVA涂抹疗法显示出极小的副作用。
结论
根据我们在新加坡中心的经验，PUVA在合理时间内对斑秃有较好的疗效。
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