Broniarczyk-Dyla Grazyna, Wawrzycka-Kaflik Anna, Dubla-Berner Malgorzata, Prusinska-Bratos Magdalena
Department of General, Esthetic Dermatology and Dermatosurgery, Medical University of Lodz, Poland.
Skinmed. 2006 Mar-Apr;5(2):64-8. doi: 10.1111/j.1540-9740.2006.04240.x.
Psoralen-UV-A (PUVA)-turban is a modification of PUVA-bath therapy used in alopecia areata.
The aim of this study was to assess the efficacy of PUVA-turban in different forms of alopecia areata. Twenty patients completed the study: nine with alopecia areata vulgaris and 11 with alopecia areata totalis or universalis.
8-methoxypsoralen in a dilution of 0.0001% (1 mg/L) was administered to the scalp for 20 minutes using a cotton towel as a turban. The application was followed by UV-A radiation. Treatments were performed two or three times weekly. The cumulative doses ranged from 48.2-253.4 J/cm2, and single fractions ranged from 0.3-6.5 J/cm2.
Hair regrowth was observed in 15 patients (total regrowth in six patients and partial regrowth in nine patients). Five patients did not respond to the therapy.
PUVA-turban was significantly more effective in alopecia areata vulgaris than in alopecia areata totalis or universalis and proved to be a safe, well tolerated method without the systemic side effects of PUVA.
补骨脂素-紫外线A（PUVA）头巾疗法是用于斑秃的PUVA浴疗法的一种改良方法。
本研究旨在评估PUVA头巾疗法对不同类型斑秃的疗效。20名患者完成了该研究：9例为寻常型斑秃，11例为全秃或普秃。
使用棉毛巾作为头巾，将浓度为0.0001%（1毫克/升）的8-甲氧基补骨脂素涂抹于头皮20分钟。涂抹后进行紫外线A照射。治疗每周进行两到三次。累积剂量范围为48.2 - 253.4焦/平方厘米，单次剂量范围为0.3 - 6.5焦/平方厘米。
15例患者出现毛发再生（6例完全再生，9例部分再生）。5例患者对治疗无反应。
PUVA头巾疗法对寻常型斑秃的疗效明显优于全秃或普秃，且被证明是一种安全、耐受性良好的方法，无PUVA的全身副作用。
