Whitmont Kaley J, Cooper Alan J
Royal North Shore Hospital, Pacific Highway, St Leonards, New South Wales, Australia.
Australas J Dermatol. 2003 May;44(2):106-9. doi: 10.1046/j.1440-0960.2003.00654.x.
The results of PUVA treatment of alopecia areata (AA) totalis and universalis were reviewed in 26 adult patients. Eight of 15 patients with AA totalis and six of 11 patients with AA universalis achieved a complete response (>90% hair regrowth). Patients with AA totalis had a greater incidence of treatment failure (<25% hair regrowth) than those with AA universalis. Patients with a family history of AA were significantly less likely to have a positive response to PUVA than those with no family history. Sex, age at diagnosis and treatment, interval between diagnosis and treatment, and background of atopy were not significant determinants of outcome. Although unable to show significance for clinical response to treatment, this study demonstrates complete hair regrowth in patients with both AA totalis (53%) and universalis (55%) while reporting a low relapse rate among these patients (21%) within a long period of follow up (mean 5.2 years).
对26例成年斑秃全秃和普秃患者补骨脂素加长波紫外线（PUVA）治疗的结果进行了回顾。15例斑秃全秃患者中有8例、11例普秃患者中有6例获得完全缓解（毛发再生>90%）。斑秃全秃患者的治疗失败率（毛发再生<25%）高于普秃患者。有斑秃家族史的患者对PUVA治疗产生阳性反应的可能性明显低于无家族史的患者。性别、诊断和治疗时的年龄、诊断与治疗之间的间隔以及特应性背景并非结局的显著决定因素。尽管该研究未能显示出对治疗临床反应的显著性，但在长期随访（平均5.2年）中，该研究证明斑秃全秃患者（53%）和普秃患者（55%）均有完全毛发再生，同时报告这些患者中的复发率较低（21%）。
