Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada.
Leuk Res. 2012 Jan;36(1):81-6. doi: 10.1016/j.leukres.2011.07.033. Epub 2011 Sep 3.
The diagnosis of blastic plasmacytoid dendritic cell neoplasm (BPDCN) can be challenging, owing to the absence of traditional lineage-specific markers, but is facilitated by CD4/CD56 co-expression and frequent skin involvement. Herein, we present our collective experiences with three BPDCN cases lacking cutaneous presentation and the inherent diagnostic pitfalls. Taken in context of similar historical cases, we suggest that BPDCN with "leukemic" presentation (L-BPDCN) otherwise presents no major distinguishing features and is at least as aggressive as its cutaneous-involved BPDCN counterpart.
原发性骨外弥漫性大 B 细胞淋巴瘤的诊断颇具挑战，因为缺乏传统的谱系特异性标志物，但 CD4/CD56 共表达和频繁的皮肤累及有助于诊断。本文报告了我们在 3 例无皮肤表现的原发性骨外弥漫性大 B 细胞淋巴瘤病例中的经验，并探讨了诊断难点。结合类似的历史病例，我们认为具有“白血病”表现的原发性骨外弥漫性大 B 细胞淋巴瘤（L-BPDCN）并无明显特征，其侵袭性至少与伴有皮肤累及的原发性骨外弥漫性大 B 细胞淋巴瘤相当。
