Bordbar Ghasem, Miri Mohammad Bagher, Omidi Mahmoud, Shoja Saeed, Akhavan Malihe
Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Department of Gastroenterology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Gastroenterol Res Pract. 2020 May 27;2020:8213082. doi: 10.1155/2020/8213082. eCollection 2020.
The unresponsiveness to conventional pharmacological treatments and their side effects have led patients with irritable bowel syndrome (IBS) to use complementary and alternative medicine such as herbal remedies. Beside, Boiss (ZM), L. (TA), and L. (AG) are being used as an antiseptic, carminative, and antispasmodic in traditional medicine. This trial investigated the efficacy and safety of a combination of ZM, AG, and TA essential oils in the treatment of IBS.
The present study was a randomized double-blind clinical trial with parallel groups in Iran. Patients in the control arm received three tablets of 10 mg hyoscine butylbromide daily for two weeks, and the intervention arm was daily treated with two 250 mg softgel capsules containing 180 mg of essential oils of ZM, AG, and TA for two weeks. Primary outcomes were the response rates based on the IBS Symptom Severity Scale (IBS-SSS), IBS Adequate Relief (IBS-AR), and IBS Global Assessment Improvement (IBS-GAI) at the end and two weeks after the end of the intervention. Secondary outcomes were the improvement rates in IBS-SSS scores, improving the quality of life, safety, and tolerability.
The posttreatment improvement percentage based on IBS-AR, IBS-GAI, and IBS-SSS scales was 83.9%, 75%, and 87% in the intervention group and 37.9%, 27.5%, and 34.4% in the control group, respectively ( < 0.001). Also, the improvement of the quality of life in the herbal medicine arm was significantly more than that in the control arm ( < 0.001).
According to the results, the herbal medicine investigated in this study can be considered an appropriate alternative treatment for IBS.
对传统药物治疗无反应及其副作用导致肠易激综合征（IBS）患者使用补充和替代医学，如草药疗法。此外，ZM、TA和AG在传统医学中被用作防腐剂、驱风剂和解痉剂。本试验研究了ZM、AG和TA精油组合治疗IBS的疗效和安全性。
本研究是在伊朗进行的一项随机双盲平行组临床试验。对照组患者每天服用3片10毫克丁溴东莨菪碱，持续两周，干预组患者每天服用2粒250毫克软胶囊，其中含有180毫克ZM、AG和TA的精油，持续两周。主要结局是干预结束时和结束后两周基于肠易激综合征症状严重程度量表（IBS-SSS）、肠易激综合征充分缓解（IBS-AR）和肠易激综合征整体评估改善（IBS-GAI）的反应率。次要结局是IBS-SSS评分的改善率、生活质量的改善、安全性和耐受性。
干预组基于IBS-AR、IBS-GAI和IBS-SSS量表的治疗后改善百分比分别为83.9%、75%和87%，对照组分别为37.9%、27.5%和34.4%（P<0.001）。此外，草药组的生活质量改善明显高于对照组（P<0.001）。
根据结果，本研究中调查的草药可被视为IBS的一种合适替代治疗方法。
