Heydari Parisa, Ghanadian Mustafa, Asghari Gholamreza, Azimi Maryam, Babaeian Mahmoud, Adibi Peyman
Department of Persian Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Res Pharm Sci. 2022 Dec 24;18(1):89-99. doi: 10.4103/1735-5362.363599. eCollection 2023 Feb.
Irritable bowel syndrome (IBS) is a disease that shows its impacts on many populations worldwide. It is known as a functional disorder of the gastrointestinal tract followed by diarrhea and fecal inconsistency. Due to the lack of treatment in the allopathic medicine system for IBS, people in the western world use different herbs as alternative medicine. In the present study, we evaluated the dried extract of against IBS.
In a randomized, double-blinded, placebo-controlled clinical trial, 76 diarrhea-predominant IBS patients were randomly assigned to two equal groups: the control group (given the placebo capsule containing 250 mg of dibasic calcium phosphate) and the treatment groups (given the capsule containing 75 mg of the dry extract of and 175 mg of dibasic calcium phosphate as filler). The study was conducted based on Rome III criteria. We studied symptoms included in Rome III criteria and divided the study into the duration of drug administration and four weeks after drug administration. These groups were compared with those of the control group.
FINDINGS/RESULTS: Significant improvements were found in the quality of life, temperament, and IBS symptoms throughout the treatment duration. Quality of life, temperature, and IBS symptoms were slightly decreased in the treatment group 4 weeks after stopping the treatment. While concluding the study, we found effective against IBS.
Whole extract of modulated symptoms of IBS patients and improved their quality of life.
肠易激综合征（IBS）是一种影响全球众多人群的疾病。它是一种胃肠道功能紊乱疾病，伴有腹泻和粪便性状异常。由于现代医学体系中缺乏针对IBS的治疗方法，西方世界的人们使用不同草药作为替代药物。在本研究中，我们评估了[草药名称未给出]的干燥提取物对IBS的疗效。
在一项随机、双盲、安慰剂对照的临床试验中，76例腹泻型IBS患者被随机分为两组，每组人数相等：对照组（给予含250毫克磷酸氢钙的安慰剂胶囊）和治疗组（给予含75毫克[草药名称未给出]干燥提取物和175毫克磷酸氢钙作为填充剂的胶囊）。该研究基于罗马Ⅲ标准进行。我们研究了罗马Ⅲ标准中包含的症状，并将研究分为给药期和给药后四周。将这些组与对照组进行比较。
在整个治疗期间，生活质量、情绪和IBS症状均有显著改善。治疗组在停药4周后，生活质量、情绪和IBS症状略有下降。在研究结束时，我们发现[草药名称未给出]对IBS有效。
[草药名称未给出]的全提取物可调节IBS患者的症状并改善其生活质量。
