Maraee Alaa, Farag Azza Gaber Antar, Gadallah Maram Mashhour, Abdou Asmaa Gaber
Dermatology, Andrology and STDs Departments, Faculty of Medicine, Menoufia University, Shebein Elkom, 32511, Egypt.
Department of Pathology, Faculty of Medicine, Menoufia University, Shebein Elkom, 32511, Egypt.
Ecancermedicalscience. 2020 May 15;14:1045. doi: 10.3332/ecancer.2020.1045. eCollection 2020.
Non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represents 78.5% of all skin malignant tumours in Egypt. Dendritic cells can be found in almost all human tumours, they play an important role in antitumour immunity. The aim of the present study was to evaluate the percentage of Langerhans cells using CD1a in non-melanoma skin cancer, including BCC and SCC and to correlate this percentage with their clinicopathological features. The current study was performed on surgically excised specimens of 41 patients presented with non-melanoma skin cancer (26 BCC and 15 SCC) and 16 healthy volunteer control subjects. The mean and median percentage of Langerhans cells were higher in normal epidermis of control compared to malignant tumour tissue (p < 0.0001) and adjacent epidermis overlying malignant tumour tissue (p = 0.007). Langerhans cells were significantly seen in BCC cases more than SCC (p = 0.035) and they were seen in facial lesions more than those arising from other sites (p = 0.007). The reduction of Langerhans cells is a way for non-melanoma skin cancer to develop and progress. Marked reduction of Langerhans cells in SCC compared to BCC could refer to their role as a barrier against metastasis.
非黑色素瘤皮肤癌，包括基底细胞癌（BCC）和鳞状细胞癌（SCC），占埃及所有皮肤恶性肿瘤的78.5%。树突状细胞几乎可见于所有人类肿瘤中，它们在抗肿瘤免疫中发挥重要作用。本研究的目的是评估利用CD1a检测非黑色素瘤皮肤癌（包括BCC和SCC）中朗格汉斯细胞的百分比，并将该百分比与其临床病理特征相关联。本研究对41例非黑色素瘤皮肤癌患者（26例BCC和15例SCC）手术切除的标本以及16名健康志愿者对照者进行。与恶性肿瘤组织相比，对照组正常表皮中朗格汉斯细胞的平均百分比和中位数百分比更高（p < 0.0001），与覆盖恶性肿瘤组织的相邻表皮相比也更高（p = 0.007）。BCC病例中朗格汉斯细胞的数量明显多于SCC（p = 0.035），面部病变中的朗格汉斯细胞数量多于其他部位的病变（p = 0.007）。朗格汉斯细胞数量减少是非黑色素瘤皮肤癌发生和发展的一种方式。与BCC相比，SCC中朗格汉斯细胞的显著减少可能与其作为转移屏障的作用有关。
