Chhabria Mamta, Venugopal Sharini, Pendela Venkata Satish, Jadhav Nagesh
Internal Medicine, Rochester General Hospital, Rochester, USA.
Cureus. 2020 May 18;12(5):e8186. doi: 10.7759/cureus.8186.
Invasive pulmonary aspergillosis (IPA) is an aggressive fungal infection of the lungs characterized by tissue invasion by fungal hyphal elements. The definitive diagnosis is challenging because it relies on histopathological demonstration of fungal elements, and these days clinicians are relying more on bronchoalveolar lavage (BAL) cultures and serum biomarkers (galactomannan and beta-D-glucan). We would like to emphasize through our case the necessity to keep a high index of suspicion for IPA despite negative cultures and serum biomarkers in immunosuppressed patients and consider surgical biopsy early.
侵袭性肺曲霉病（IPA）是一种侵袭性肺部真菌感染，其特征是真菌菌丝成分侵入组织。明确诊断具有挑战性，因为它依赖于真菌成分的组织病理学证明，如今临床医生更多地依赖支气管肺泡灌洗（BAL）培养和血清生物标志物（半乳甘露聚糖和β-D-葡聚糖）。我们希望通过我们的病例强调，对于免疫抑制患者，尽管培养和血清生物标志物呈阴性，仍需对IPA保持高度怀疑，并尽早考虑手术活检。
