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自体干细胞移植后多发性骨髓瘤孤立性中枢神经系统复发——一种罕见表现。

Isolated central nervous system relapse of multiple myeloma post autologous stem cell transplant- A rare presentation.

作者信息

Mittal Abhenil, Pushpam Deepam, Kumar Lalit

机构信息

Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Room no 245, DRBRAIRCH, New Delhi, India.

出版信息

Leuk Res Rep. 2020 Jun 8;14:100207. doi: 10.1016/j.lrr.2020.100207. eCollection 2020.

DOI:10.1016/j.lrr.2020.100207
PMID:32566478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7296331/
Abstract

•CNS relapse in multiple myeloma after ASCT without medullary relapse is uncommon.•Isolated CNS relapse is extremely rare with only 7 cases reported in literature.•Prognosis is poor with very short median survival after detection of CNS relapse.•Management is based on IMiD's and intrathecal therapy with radiation.

摘要

•自体造血干细胞移植（ASCT）后无髓内复发的多发性骨髓瘤中枢神经系统（CNS）复发并不常见。

•孤立性CNS复发极为罕见，文献中仅报道了7例。

•CNS复发检测后中位生存期极短，预后较差。

•治疗基于免疫调节药物（IMiD）和鞘内注射联合放疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/7296331/ce31c43f6721/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/7296331/460822ce8151/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/7296331/ce31c43f6721/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/7296331/460822ce8151/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e1b/7296331/ce31c43f6721/gr2.jpg

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Case Rep Hematol. 2020 Jan 3;2020:8563098. doi: 10.1155/2020/8563098. eCollection 2020.
2
Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature.中枢神经系统多发性骨髓瘤：13例病例及文献综述
J Oncol. 2018 Apr 23;2018:3970169. doi: 10.1155/2018/3970169. eCollection 2018.
3
Durable treatment response of relapsing CNS plasmacytoma using intrathecal chemotherapy, radiotherapy, and Daratumumab.
使用鞘内化疗、放疗和达雷妥尤单抗治疗复发性中枢神经系统浆细胞瘤的持久治疗反应
Clin Case Rep. 2018 Mar 2;6(4):723-728. doi: 10.1002/ccr3.1451. eCollection 2018 Apr.
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Case Rep Oncol. 2017 Jul 4;10(2):582-587. doi: 10.1159/000478001. eCollection 2017 May-Aug.
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