Pan Jonathan, Chen Jason, Filicko Joanne, Grosso Dolores, Nagurney Michelle, Alpdogan Onder, Flomenberg Neal
Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Case Rep Oncol. 2017 Jul 4;10(2):582-587. doi: 10.1159/000478001. eCollection 2017 May-Aug.
Although rare, both central nervous system and pericardial involvement of myeloma have been well described in the literature. Their simultaneous occurrence in relapsed disease, however, has not been previously reported. This case describes a 54-year-old female who was treated for high-risk multiple myeloma with multiregimen chemotherapy and allogeneic hematopoietic stem cell transplantation. Four months after transplant, she was found to have relapsed disease manifesting as an extraosseous, intracranial plasmacytoma and simultaneous malignant pericardial effusion. Her disease characteristics, treatment course, radiologic and pathologic findings are described in detail, and we review the previous literature to determine the various aspects of her disease that may have contributed to her aggressive clinical course.
尽管骨髓瘤累及中枢神经系统和心包的情况较为罕见，但在文献中已有详尽描述。然而，它们在复发疾病中同时出现的情况此前尚未见报道。本病例描述了一名54岁女性，她接受了多方案化疗和异基因造血干细胞移植治疗高危多发性骨髓瘤。移植后四个月，发现她疾病复发，表现为骨外颅内浆细胞瘤并同时伴有恶性心包积液。详细描述了她的疾病特征、治疗过程、影像学和病理学发现，并回顾了既往文献以确定其疾病可能导致侵袭性临床病程的各个方面。
