Arslan Hakan, Gündoğdu Eyüp Candaş, Sümbüllü Meltem
Department of Endodontics, Erzurum Atatürk University School of Dentistry, Erzurum, Turkey.
Eur Endod J. 2016 Sep 29;1(1):1-5. doi: 10.5152/eej.2016.16012. eCollection 2016.
To compare the effect of preoperative administration of an antihistamine, an analgesic, or a placebo on postoperative pain in maxillary molar teeth with symptomatic apical periodontitis.Design: A randomized, controlled trial.
Population: A total of 51 patients with moderate-to-severe maxillary molar tooth pain who have undergone a root canal treatment.Intervention: Preoperative administration of either an antihistamine or an analgesic.Control: Versus placeboOutcomes: Reduction in postoperative pain? The data were analyzed with chi-square, one-way analysis of variance (ANOVA) and least significant difference (LSD) post-hoc tests.
At days 1 and 3, preoperative administration of the antihistamine and analgesic resulted in lower pain levels than the placebo. At days 5 and 7, however, while preoperative administration of the antihistamine still resulted in less pain than the placebo, there was no significant difference between the analgesic and placebo (P>0.05).
Within the limitations of the present study, the preoperative administration of an antihistamine can be beneficial in reducing the postoperative pain of endodontic treatments.
比较术前给予抗组胺药、镇痛药或安慰剂对上颌磨牙症状性根尖周炎术后疼痛的影响。
一项随机对照试验。
共有51例中度至重度上颌磨牙疼痛且已接受根管治疗的患者。
术前给予抗组胺药或镇痛药。
与安慰剂对照
术后疼痛减轻情况？数据采用卡方检验、单因素方差分析（ANOVA）和最小显著差异（LSD）事后检验进行分析。
在第1天和第3天，术前给予抗组胺药和镇痛药的患者疼痛程度低于安慰剂组。然而，在第5天和第7天，虽然术前给予抗组胺药的患者疼痛仍比安慰剂组轻，但镇痛药组与安慰剂组之间无显著差异（P>0.05）。
在本研究的局限性范围内，术前给予抗组胺药有助于减轻牙髓治疗后的术后疼痛。
