Department of Pediatric, Hematology and Oncology, Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Pediatric, Hematology and Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Leuk Lymphoma. 2020 Nov;61(11):2674-2681. doi: 10.1080/10428194.2020.1779260. Epub 2020 Jun 22.
Higher incidence and poorer outcomes of acute lymphoblastic leukemia (ALL) in Hispanic Americans have been attributed to high-risk molecular markers associated with Native American (NA) ancestry. However, the diverse Hispanic populations in the United States differ substantially in ancestry. Continental Hispanics have a high proportion of NA ancestry while Caribbean Hispanics have a lower proportion of NA ancestry. Here, we analyzed mortality data of 2428 children and adults with ALL. Mortality rates were age-adjusted and compared by race and ethnicity using negative binomial regression with particular attention to distinct Hispanic populations. While both Continental (mortality rate ratio (MRR) 2.09, 95% CI 1.82-2.39) and Caribbean (MRR 1.27, 95% CI 1.05-1.54) Hispanics had higher mortality rates than other racial and ethnic groups, Continental Hispanics had significantly higher mortality rates than Caribbean Hispanics. This is the first study to demonstrate a clear difference in ALL mortality by Hispanic group on a population basis.
美国西班牙裔人群中急性淋巴细胞白血病（ALL）的发病率更高，预后更差，这归因于与美洲原住民（NA）血统相关的高危分子标志物。然而，美国多样化的西班牙裔人群在血统上有很大的差异。大陆西班牙裔人群的 NA 血统比例较高，而加勒比西班牙裔人群的 NA 血统比例较低。在这里，我们分析了 2428 名 ALL 儿童和成人的死亡率数据。使用负二项式回归对年龄调整后的死亡率进行了比较，并根据种族和族裔进行了比较，特别关注不同的西班牙裔人群。虽然大陆西班牙裔（死亡率比（MRR）2.09，95%CI 1.82-2.39）和加勒比西班牙裔（MRR 1.27，95%CI 1.05-1.54）的死亡率均高于其他种族和族裔群体，但大陆西班牙裔的死亡率明显高于加勒比西班牙裔。这是第一项基于人群的研究，表明在 ALL 死亡率方面，西班牙裔人群之间存在明显差异。
