Dai Xin, Deng Yongtao, Luo Yetao, Xie Jianghong, Ma Houxun
Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University.
Clinical Epidemiology and Biostatistics Department, Department of Pediatric Research Institute, Children's Hospital Affiliated with Chongqing Medical University, Chongqing, China.
Medicine (Baltimore). 2020 Jun 19;99(25):e20831. doi: 10.1097/MD.0000000000020831.
The objective was to investigate the association of different hydration doses and its effect on renal function in patients with primary osteoporosis treated with zoledronic acid.The subjects with primary osteoporosis treated with zoledronic acid at the First Affiliated Hospital of Chongqing Medical University, China, from January 2015 to December 2018 were included in this study. The subjects were classified according to different hydration doses. Renal function indexes before and after treatment were collected and adverse reactions recorded to analyze the changes in renal function associated with different hydration doses.The choice of the hydration dose treated with zoledronic acid deserves attention. The lower hydration dose is, the greater impact on renal function can be caused.
目的是探讨不同水化剂量与唑来膦酸治疗原发性骨质疏松症患者肾功能的关系。纳入2015年1月至2018年12月在中国重庆医科大学附属第一医院接受唑来膦酸治疗的原发性骨质疏松症患者。根据不同水化剂量对受试者进行分类。收集治疗前后的肾功能指标并记录不良反应，以分析不同水化剂量与肾功能变化的关系。唑来膦酸治疗时水化剂量的选择值得关注。水化剂量越低，对肾功能的影响可能越大。
