Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Department of Neonatology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Am J Ophthalmol. 2020 Nov;219:177-185. doi: 10.1016/j.ajo.2020.06.001. Epub 2020 Jun 20.
To evaluate the foveal development in preterm children with optical coherence tomography and OCT angiography.
Retrospective cohort study.
This study included children aged 6-8 years who were born prematurely and who did not receive retinopathy treatment. They were evaluated between September 2018 and July 2019, categorized according to gestational age (GA) (group I: GA ≤30 weeks; group II: GA between 31 and 34 weeks), and compared with full-term children (group III). Central foveal thickness (CFT), inner retinal thickness (IRT), outer retinal thickness (ORT), subfoveal choroidal thickness (CT), temporal and nasal CT, foveal avascular zone (FAZ) diameter, and vessel densities of superficial (SCP-VD) and deep capillary plexuses (DCP-VD) of the foveal and parafoveal areas were examined in detail.
The study included 126 eyes of 63 patients (group I: 40 eyes; group II: 46 eyes; and group III: 40 eyes). In group I, CFT, IRT, ORT, foveal SCP-VD, and foveal DCP-VD were significantly greater than those in the other groups, and temporal CT and FAZ diameter were significantly lower (P < .05). GA showed a significant negative correlation with CFT, IRT, ORT, foveal SCP-VD, and foveal DCP-VD and a significant positive correlation with subfoveal CT, temporal and nasal CT, and FAZ diameter (P < .05).
The morphological and vascular foveal structures in early school-age children who were born premature were different from those of full-term children. These differences were correlated with GA and more pronounced in those with GA of ≤30 weeks.
利用光学相干断层扫描和 OCT 血管造影评估早产儿的黄斑发育情况。
回顾性队列研究。
本研究纳入了年龄在 6-8 岁之间、未经视网膜病变治疗的早产儿。研究时间为 2018 年 9 月至 2019 年 7 月，根据胎龄（GA）进行分组（I 组：GA≤30 周；II 组：GA 在 31-34 周之间），并与足月产儿（III 组）进行比较。详细检查了中心凹视网膜厚度（CFT）、内视网膜厚度（IRT）、外视网膜厚度（ORT）、黄斑下脉络膜厚度（CT）、颞侧和鼻侧 CT、黄斑中心凹无血管区（FAZ）直径以及黄斑和旁中心凹区浅层毛细血管丛（SCP-VD）和深层毛细血管丛（DCP-VD）的血管密度。
本研究纳入了 63 例患者的 126 只眼（I 组：40 只眼；II 组：46 只眼；III 组：40 只眼）。I 组的 CFT、IRT、ORT、黄斑 SCP-VD 和黄斑 DCP-VD 明显大于其他组，而颞侧 CT 和 FAZ 直径明显较小（P<.05）。GA 与 CFT、IRT、ORT、黄斑 SCP-VD 和黄斑 DCP-VD 呈显著负相关，与黄斑下 CT、颞侧和鼻侧 CT 以及 FAZ 直径呈显著正相关（P<.05）。
早产早期儿童的形态学和血管性黄斑结构与足月产儿不同，这些差异与 GA 相关，GA≤30 周的早产儿更为显著。
