Hangil Eye Hospital, Incheon, Republic of Korea.
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Sci Rep. 2023 Feb 22;13(1):3130. doi: 10.1038/s41598-023-30166-1.
In this study, foveal, parafoveal, peripapillary anatomical, and microvascular anomalies in prematurely born children aged 4-12 years with a history of retinopathy of prematurity (ROP) were evaluated. Seventy-eight eyes of 78 prematurely born children ([tROP]: ROP with laser treatment, [srROP]: spontaneously regressed ROP) and 43 eyes of 43 healthy children were included. Foveal and peripapillary morphological parameters (including ganglion cell and inner plexiform layer (GCIPL) thickness, peripapillary retinal nerve fiber layer (pRNFL) thickness) and vasculature parameters (including foveal avascular zone area, vessel density from superficial retinal capillary plexus (SRCP), deep retinal capillary plexus (DRCP), and radial peripapillary capillary (RPC) segments) were analyzed. Foveal vessel densities in SRCP and DRCP were increased and parafoveal vessel densities in SRCP and RPC segments vessel density were decreased in both ROP groups compared with those of control eyes. The best-corrected visual acuity was negatively correlated with pRNFL thickness in the tROP group. Refractive error was negatively correlated with vessel density of RPC segments in the srROP group. In children born preterm with a history of ROP, it was found that foveal, parafoveal, and peripapillary structural and vascular anomalies and redistribution were accompanied. These retinal vascular and anatomical structure anomalies showed close relationships with visual functions.
本研究评估了有早产儿视网膜病变（ROP）病史的 4-12 岁儿童的黄斑、旁中心、视盘周围解剖和微血管异常。共纳入 78 只眼（[tROP]：ROP 经激光治疗，[srROP]：自发消退的 ROP）和 43 只眼（[srROP]：自发消退的 ROP）的 78 名早产儿和 43 名健康儿童。分析了黄斑和视盘周围形态参数（包括神经节细胞和内丛状层（GCIPL）厚度、视盘周围视网膜神经纤维层（pRNFL）厚度）和血管参数（包括黄斑无血管区面积、浅层视网膜毛细血管丛（SRCP）、深层视网膜毛细血管丛（DRCP）和放射状视盘周围毛细血管（RPC）段的血管密度）。与对照组相比，tROP 组的 SRCP 和 DRCP 黄斑区血管密度增加，SRCP 和 RPC 段旁中心区血管密度降低。tROP 组最佳矫正视力与 pRNFL 厚度呈负相关。srROP 组的屈光不正与 RPC 段的血管密度呈负相关。在有 ROP 病史的早产儿中，发现存在黄斑、旁中心和视盘周围的结构和血管异常以及再分布。这些视网膜血管和解剖结构异常与视觉功能密切相关。
