过敏皮肤炎症与金黄色葡萄球菌皮肤定植互为增强。
Allergic skin inflammation and S. aureus skin colonization are mutually reinforcing.
机构信息
Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
出版信息
Clin Immunol. 2020 Sep;218:108511. doi: 10.1016/j.clim.2020.108511. Epub 2020 Jun 20.
Abstract
Atopic dermatitis (AD) lesional skin is often colonized with S. aureus, and the load of S. aureus correlates with disease severity. However, a causative and mechanistic link between S. aureus skin colonization and severity of AD is not well established. We made use of well-established mouse model of AD elicited by epicutaneous sensitization of tape stripped skin with ovalbumin to investigate the relationship between allergic skin inflammation and cutaneous S. aureus colonization. Topical application of S aureus exacerbated allergic skin inflammation induced by epicutaneous sensitization with ovalbumin, whereas allergic skin inflammation generated a permissive environment for S. aureus persistence. Our results establish a mutually reinforcing role of allergic skin inflammation and S. aureus skin colonization.
摘要
特应性皮炎（AD）病变皮肤常定植有金黄色葡萄球菌（S. aureus），且金黄色葡萄球菌的负荷与疾病严重程度相关。然而，金黄色葡萄球菌皮肤定植与 AD 严重程度之间的因果和机制联系尚未得到很好的建立。我们利用经皮胶带撕脱皮肤用卵清蛋白致敏诱导的 AD 小鼠模型，研究了过敏性皮肤炎症与金黄色葡萄球菌皮肤定植之间的关系。金黄色葡萄球菌的局部应用加剧了经皮致敏卵清蛋白诱导的过敏性皮肤炎症，而过敏性皮肤炎症为金黄色葡萄球菌的持续存在创造了有利环境。我们的结果确立了过敏性皮肤炎症和金黄色葡萄球菌皮肤定植之间的相互增强作用。
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