Seiger A
Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden.
Fetal Ther. 1988;3(1-2):8-13. doi: 10.1159/000263328.
A recent promising development in the field of central nervous system (CNS) transplantation has suggested the use of human fetal CNS tissue from first trimester abortions for xenografting/explantation. Such experiments would certainly expand our knowledge of the normal developmental mechanisms in human CNS, and allow studies of various indices of maturation and CNS function. However, the suggestion is looked upon with hesitance for ethical, legal and perhaps even for scientific reasons. The initial experiments have been very valuable, though, for our understanding of the structural and functional development of the human CNS, and several legal and ethical concerns have been addressed in working out the procedures for retrieving such tissue. This article tries to put our present knowledge in the right perspective of scientific achievements and potential, legal restrictions and ethical concerns.
中枢神经系统（CNS）移植领域最近一项有前景的进展表明，可将孕早期流产的人类胎儿中枢神经系统组织用于异种移植/移出移植。此类实验肯定会拓展我们对人类中枢神经系统正常发育机制的认识，并能对各种成熟指标和中枢神经系统功能进行研究。然而，出于伦理、法律甚至可能还有科学方面的原因，这一建议遭到了犹豫对待。不过，最初的实验对于我们理解人类中枢神经系统的结构和功能发育非常有价值，并且在制定获取此类组织的程序时已经解决了一些法律和伦理问题。本文试图从科学成就与潜力、法律限制以及伦理关注的正确角度阐述我们目前的认识。
