Two cases of septic shock with different outcomes caused by non-O1/non-O139 isolates.

In recent decades, increasing numbers of human infections have been linked to non-O1/non-O139 . Septicemia resulting from non-O1/non-O139 infection is rare but has high mortality. The pathogenesis of non-O1/non-O139 septicemia is poorly understood. Here, we report two sporadic cases of septicemia following non-O1/non-O139 infection from an inland area of China. Patient 1 died rapidly within 24 hours, while patient 2 gradually recovered from septic shock. To explore the reasons for these divergent outcomes, we compared the two cases, tested the antibiotic sensitivity of the two isolates, and investigated their virulence genes and sequence types.