Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Department of Blood Transfusion, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
J Int Med Res. 2020 Jun;48(6):300060520933459. doi: 10.1177/0300060520933459.
In recent decades, increasing numbers of human infections have been linked to non-O1/non-O139 . Septicemia resulting from non-O1/non-O139 infection is rare but has high mortality. The pathogenesis of non-O1/non-O139 septicemia is poorly understood. Here, we report two sporadic cases of septicemia following non-O1/non-O139 infection from an inland area of China. Patient 1 died rapidly within 24 hours, while patient 2 gradually recovered from septic shock. To explore the reasons for these divergent outcomes, we compared the two cases, tested the antibiotic sensitivity of the two isolates, and investigated their virulence genes and sequence types.
近几十年来，越来越多的人类感染与非 O1/非 O139 有关。非 O1/非 O139 感染导致的败血症很少见，但死亡率很高。非 O1/非 O139 败血症的发病机制尚不清楚。在这里，我们报告了两例来自中国内陆地区的非 O1/非 O139 感染引起的败血症散发病例。患者 1 在 24 小时内迅速死亡，而患者 2 逐渐从感染性休克中恢复。为了探讨这些不同结果的原因，我们比较了这两个病例，测试了两个分离株的抗生素敏感性，并研究了它们的毒力基因和序列类型。
