Deshayes S, Daurel C, Cattoir V, Parienti J-J, Quilici M-L, de La Blanchardière A
Service des Maladies Infectieuses et Tropicales, CHU Côte de Nacre, avenue Côte de Nacre, 14033 Caen Cedex 9, France.
Service de Microbiologie, CHU Côte de Nacre, avenue Côte de Nacre, 14033 Caen Cedex 9, France.
Springerplus. 2015 Oct 5;4:575. doi: 10.1186/s40064-015-1346-3. eCollection 2015.
Non-O1, non-O139 Vibrio cholerae (NOVC) are increasingly frequently observed ubiquitous microorganisms occasionally responsible for intestinal and extra-intestinal infections. Most cases involve self-limiting gastroenteritis or ear and wound infections in immunocompetent patients. Bacteraemia, which have been described in patients with predisposing factors, are rare and poorly known, both on the clinical and therapeutic aspects. We describe a case of NOVC bacteraemia and a systematic literature review in PubMed conducted up to November 2014 using a combination of the following search terms: "Vibrio cholerae non-O1" and "bacter(a)emia". The case was a 70 year-old healthy male subject returning from Senegal and suffering from NOVC bacteraemia associated with liver abscesses. Disease evolution was favourable after 2 months' therapy (ceftriaxone then ciprofloxacin). Three hundred and fifty cases of NOVC bacteraemia have been identified in the literature. The majority of patients were male (77 %), with a median age of 56 years and presenting with predisposing conditions (96 %), such as cirrhosis (55 %) or malignant disease (20 %). Diarrhoea was inconstant (42 %). Mortality was 33 %. The source of infection, identified in only 25 % of cases, was seafood consumption (54 %) or contaminated water (30 %). Practitioners should be aware of these infections, in order to warn patients with predisposing conditions, on the risk of ingesting raw or undercooked seafood or bathing in potentially infected waters.
非O1群、非O139群霍乱弧菌（NOVC）是一种越来越常见的普遍存在的微生物，偶尔会导致肠道和肠道外感染。大多数病例为免疫功能正常患者的自限性胃肠炎或耳部及伤口感染。在有易感因素的患者中所描述的菌血症较为罕见，在临床和治疗方面都鲜为人知。我们报告一例NOVC菌血症病例，并在PubMed上进行了一项系统的文献综述，检索截至2014年11月，使用了以下搜索词组合：“非O1群霍乱弧菌”和“菌血症”。该病例为一名70岁健康男性，从塞内加尔回国后患上与肝脓肿相关的NOVC菌血症。经过2个月的治疗（先使用头孢曲松，然后使用环丙沙星），病情好转。文献中已确定350例NOVC菌血症病例。大多数患者为男性（77%），中位年龄为56岁，且有易感疾病（96%），如肝硬化（55%）或恶性疾病（20%）。腹泻情况不一（42%）。死亡率为33%。仅在25%的病例中确定了感染源，为食用海鲜（54%）或受污染的水（30%）。从业者应了解这些感染情况，以便警告有易感疾病的患者，食用生的或未煮熟海鲜或在可能受感染的水中沐浴的风险。
