Schuster D P, Mintun M A
Department of Internal Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110.
J Thorac Imaging. 1988 Jan;3(1):15-24. doi: 10.1097/00005382-198801000-00004.
Positron emission tomography and appropriately labeled, short-lived radiopharmaceuticals can be used to study a variety of physiologic processes within the lung. Recently, methods have been developed to measure regional pulmonary blood flow and pulmonary vascular permeability to protein macromolecules. The advantages of these techniques include accurate quantitation, regional data available in an image format, noninvasiveness, and repeatability. These methods have recently been applied to studies of hypoxic vasoconstriction, pulmonary edema, and chronic obstructive lung disease in man and large experimental animals. Although the technology is complex and requires the integration of people from a variety of disciplines, these methods offer a unique opportunity to study in vivo lung physiology.
正电子发射断层扫描以及经过适当标记的短寿命放射性药物可用于研究肺内的多种生理过程。最近，已经开发出测量局部肺血流量和肺血管对蛋白质大分子通透性的方法。这些技术的优点包括准确定量、以图像形式提供局部数据、非侵入性和可重复性。这些方法最近已应用于人类和大型实验动物的低氧性血管收缩、肺水肿和慢性阻塞性肺疾病的研究。尽管该技术复杂，需要多学科人员的协作，但这些方法为研究活体肺生理学提供了独特的机会。
