Mintun M A, Ter-Pogossian M M, Green M A, Lich L L, Schuster D P
J Appl Physiol (1985). 1986 Jan;60(1):317-26. doi: 10.1152/jappl.1986.60.1.317.
We have measured regional pulmonary blood flow (PBF) in normal dogs with positron emission tomography (PET) and 15O-labeled water (H2(15)O). The method is nondestructive, quantitative, and repeatable. To measure PBF, PET is used to measure both the initial and equilibrium distribution of lung activity after H2(15)O infusion. The data are then interpreted with a one-compartment mathematical model. Measurements of PBF in dogs with H2(15)O (PBF-water) were compared with PBF measured with 68Ga microspheres (PBF-MS), and a close correlation was observed: PBF-water = 0.82 PBF-MS + 25.4 (R = 0.97, n = 52). In another set of animals an important assumption of the method, namely that the tracer is fully extracted during a single pass through the lung, was demonstrated using a single-probe residue-detection technique. Computer simulations were performed to illustrate the sensitivity of the method to errors in the measured variables of tracer activity or tissue-blood partition coefficient. Results showed only small error magnification for the range of values observed in these studies.
我们使用正电子发射断层扫描（PET）和15O标记水（H2(15)O）测量了正常犬的局部肺血流量（PBF）。该方法具有无损、定量和可重复的特点。为了测量PBF，PET用于测量注入H2(15)O后肺内放射性的初始分布和平衡分布。然后用单室数学模型对数据进行解释。将用H2(15)O测量的犬的PBF（PBF-水）与用68Ga微球测量的PBF（PBF-MS）进行比较，观察到密切相关性：PBF-水 = 0.82 PBF-MS + 25.4（R = 0.97，n = 52）。在另一组动物中，使用单探头残留检测技术证明了该方法的一个重要假设，即示踪剂在单次通过肺时被完全摄取。进行了计算机模拟以说明该方法对示踪剂活性或组织-血液分配系数测量变量误差的敏感性。结果表明，在这些研究中观察到的值范围内，误差放大很小。
