暴露于交联的IgD可在体内和体外诱导T细胞上的IgD受体。
Exposure to crosslinked IgD induces receptors for IgD on T cells in vivo and in vitro.
作者信息
Coico R F, Finkelman F, Swenson C D, Siskind G W, Thorbecke G J
机构信息
City University of New York Medical School, NY 10031.
出版信息
Proc Natl Acad Sci U S A. 1988 Jan;85(2):559-63. doi: 10.1073/pnas.85.2.559.
IgD is a surface immunoglobulin, which is coexpressed with IgM on greater than 90% of mature B cells, but its levels in serum are extremely low compared to those of IgM. It role as a surface receptor has been reemphasized by our recent findings that IgD receptors are induced on helper T cells by exposure to IgD and that such cells have immunoaugmenting properties. The present study shows that crosslinking of soluble IgD or of monomeric cell surface IgD is required and sufficient for the induction of T cells bearing receptors for IgD, both in vivo and in vitro. Effective IgD crosslinking in this respect can be obtained with antigen or with heterologous and immunogenic as well as nonimmunogenic allotype-specific anti-IgD. These results reinforce the concept that the induction of T cells bearing receptors for IgD is an integral component of the normal immune response.
IgD是一种表面免疫球蛋白，在超过90%的成熟B细胞上与IgM共表达，但其血清水平与IgM相比极低。我们最近的研究结果再次强调了其作为表面受体的作用，即辅助性T细胞在接触IgD后可诱导产生IgD受体，且此类细胞具有免疫增强特性。本研究表明，无论是在体内还是体外，可溶性IgD或单体细胞表面IgD的交联对于诱导带有IgD受体的T细胞都是必需且充分的。在这方面，使用抗原、异源和免疫原性以及非免疫原性的同种异型特异性抗IgD均可实现有效的IgD交联。这些结果强化了这样一种概念，即诱导带有IgD受体的T细胞是正常免疫反应的一个组成部分。
Zotero 插件