Coico R F, Xue B, Wallace D, Pernis B, Siskind G W, Thorbecke G J
Nature. 1985;316(6030):744-6. doi: 10.1038/316744a0.
The role of IgD in the immune response has been elusive, although its predominance on the cell surface suggests a receptor function. We have shown previously that euthymic but not athymic BALB/c mice, injected with IgD before antigen, exhibit enhanced antibody responses which can be transferred by T cells. Isotype-specific T cells have been reported to have both upward and downward immunoregulatory effects. Here we demonstrate the existence of T cells with receptors for IgD, and show that exposure to IgD in vivo or in vitro significantly increases the number of T delta cells in the spleen and lymph nodes but not in the thymus. The kinetics of T delta-cell appearance in vivo parallels that of the immunoenhancing effect which occurs after injection of IgD. These T delta cells are of the Lyt 1+2- T-cell phenotype.
尽管IgD在细胞表面占优势表明其具有受体功能，但其在免疫反应中的作用一直难以捉摸。我们之前已经表明，在抗原之前注射IgD的正常胸腺而非无胸腺的BALB/c小鼠，会表现出增强的抗体反应，这种反应可由T细胞传递。据报道，同型特异性T细胞具有上调和下调的免疫调节作用。在这里，我们证明了存在具有IgD受体的T细胞，并表明体内或体外暴露于IgD会显著增加脾脏和淋巴结中Tδ细胞的数量，但胸腺中不会。体内Tδ细胞出现的动力学与注射IgD后发生的免疫增强作用的动力学相似。这些Tδ细胞具有Lyt 1+2-T细胞表型。
